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The relationship between the function of red blood cell immune adherence and lipid peroxidation during cerebral ischemia and reperfusion in gerbil

Ding Suju; Guo Feng; Zheng Huimin; Zhang Renqin; Hou Xiaojun (Department of Neurology,Changhai Hospital, Second Military Medical University, Shanghai, 200433)  
This experiment studied the functional changes of red blood cell immune adherence (RCIA) and lipid peroxidation during cerebral ischemia-reperfusion in gerbil.Red blood cell C3b receptor rosette (RBC-C3bRR), red blood cell immune complex rosette (RBC-ICR), red blood cell superoxidate dismustase (RBC-SOD) and red blood cell malonialdehyde (RBC-MDA) were determined. Results showed that (1) RBC-C3bRR didn't decrease in the ischemic group(P0.05), while markedly decreased in the reperfusion group (P0.001). RBC-ICR increased in the ischemic group (P0.01), and in the reperfusion group (P0.001); (2) RBC-SOD lightly decreased (P0.05) in the ischemic group and in the reperfusion group, while RBC-MDA significantly increased (P0.01) in the reperfusion group; (3) The functional change of RCIA in cerebral ischemia-reperfusion related with RBC-MDA.It suggests that blocking the lipid peroxidative reaction to stabilize the regulation of RCIA in blood reperfusion after cerebral ischemia is very important.
【CateGory Index】: R743.310.2
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