Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Intelligent Computer and Applications》 2019-04
Add to Favorite Get Latest Update

Multi classification of Alzheimer's disease using linear fusion with images and indicators

CHU Jiahuan;PAN Qiao;School of Computer Science and Technology,Donghua University;  
With the development of artificial intelligence,computer-aided diagnosis plays an increasingly important role in the diagnosis of Alzheimer's disease. This paper proposes a newmulti-classification diagnostic model based on images and indicators fusion. TOP-MRI image and clinical indicator features are fully exploited for multi-classification diagnosis of Alzheimer's disease.Firstly,a TOP-CNN-NN model consisting of three VGGNet-16 convolutional neural networks and a single hidden layer network is constructed to extract the feature vector of TOP-MRI images of the brain,then CfsSubsetEval evaluator is used to screen the feature vector of clinical indicators. Secondly,the image feature vector and the indicator feature vector are linearly fused by Canonical Correlation Analysis(CCA). Finally,the vector is inputted into multi-classifier,which is used to distinguish three stages of Alzheimer's disease,including normal(CN),mild cognitive impairment(MCI) and Alzheimer's disease(AD). Experiments showthat the accuracy of the proposed method in multi-classification diagnosis of Alzheimer's disease can reach 86.7%,and it has good performance.
【Fund】: 上海市经信委人工智能创新发展专项资金(RX-RJJC-08-16-0483 2017-RGZN-01004)
【CateGory Index】: TP391.41;R749.16
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Zhang Jingshuang;Wang Rong;Department of Central Laboratory,Xuanwu Hospital,Capital Medical University,Beijing Geriatric Medical Research Center,Center of Alzheimer's Disease,Beijing Institute for Brain Disorders,Key Laboratory for Neurodegenerative Disease of Ministry of Education;;Research progress in the pathogenesis of Alzheimer's disease[J];首都医科大学学报;2014-06
2 CHEN Yi;ZHANG Bao-Rong;Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine;;Research progress of core biomarkers related to Alzheimer's disease[J];生命科学;2014-01
3 SUN Quan-Sen~1),2) ZENG Sheng-Gen~1) HENG Pheng-Ann~3) XIA De-Shen~1)~1)(Department of Computer Science, Nanjing University of Science &Technology, Nanjing 210094)~2)(School of Science, Jinan University, Jinan 250022)~3)(Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong);The Theory of Canonical Correlation Analysis and Its Application to Feature Fusion[J];计算机学报;2005-09
Chinese Journal Full-text Database 10 Hits
1 Fan Zhao;Yang Yachao;Xu Fanyu;Qi Xuedan;Key Laboratory of Cellular Physiology,Ministry of Education,Department of Physiology,Department of Stomatology,Shanxi Medical University;;A mathematical model for prediction of Alzheimer's disease progression based on MRI database[J];中华生物医学工程杂志;2016-02
2 JIANG Wen;QI Lin;School of Information Engineering,Zhengzhou University;;An improved supervised sparsity preserving CCA algorithm based on exponential dimensionality reduction[J];郑州轻工业学院学报(自然科学版);2015-Z2
3 ZHAI Shaolei;CAO Min;SHEN Xin;WANG Fei;WANG En;Electric Power Research Institute, Yunnan Power Grid Co., Ltd.;;Multidimensional Information of Aggregation Technology for On-line Monitoring of Substation[J];高电压技术;2015-12
4 Bao Xunjie;Cai yanning;Zhu Yanqiu;Yang Cuicui;Li Lin;Zhang Lan;Department of Pharmacology,Xuanwu Hospital,Capital Medical University;Key Laboratory for Neurodegenerative Diseases of Ministry of Education;Department of Neurobiology,Xuanwu Hospital,Capital Medical University;;Promoter methylation analysis of seven clock genes in the brain of 3xTg mice[J];首都医科大学学报;2015-06
5 YANG Ya-chao;XU Fan-yu;FAN Zhao;Department of Physiology,Basic Medical Sciences of Shanxi Medical University;Department of Oral Medicine,Shanxi Medical University;Centre for Translational Medicine,Shanxi Medical University;;Analysis the early mild cognitive dysfunction and Alzheimer′s disease and correlation study between MRI and MMSE score[J];中国当代医药;2015-29
6 JIN he;WANG rong;Central Laboratory,Xuan Wu Hospital,Capital Medical University;Center of Alzheimer's Disease,Beijing Institute for Brain Disorders;Key Laboratory for Neurodegenerative Disease of Ministry of Education;Beijing Geriatric Medical Research Center;;Research progress of the relationship between autophagy andβ-amyloid peptide in Alzheimer's diseese[J];中国比较医学杂志;2015-08
7 Zhang Bo;Hao Jie;Ma Gang;Yue Jinpeng;Zhang Jianhua;Shi Zhongzhi;Key Laboratory of Intelligent Information Processing,Institute of Computing Technology,Chinese Academy of Sciences;University of Chinese Academy of Sciences;School of Computer Science and Technology,China University of Mining and Technology;School of Medicine Information,Xuzhou Medical College;;Mixture of Probabilistic Canonical Correlation Analysis[J];计算机研究与发展;2015-07
8 DENG He-chun;Dongcheng Street Community Health Center of Dongguan;;The risk factors analysis of alzheimer's disease[J];临床合理用药杂志;2015-19
9 LI Wen-Ping;YANG Jing;YIN Gui-Sheng;ZHANG Jian-Pei;College of Computer Science and Technology,Harbin Engineering University;College of Mathematics Physics and Information Engineering,Jiaxing University;;Data Field Based Canonical Correlation Analysis and Its Application to Image Segmentation[J];自动化学报;2015-04
10 ZHANG Xiongmei;YI Zhaoxiang;CAI Xingfu;SONG Jianshe;The Second Artillery Engineering University;;SAR Image Registration Method Based on Improved SIFT[J];计算机工程;2015-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Zhichun Chen;Chunjiu Zhong;Department of Neurology, Zhongshan Hospital;The State Key Laboratory of Medical Neurobiology, Fudan University;The Institutes of Brain Science, Fudan University;;Oxidative stress in Alzheimer's disease[J];Neuroscience Bulletin;2014-02
2 CHEN Yi;ZHANG Bao-Rong;Department of Neurology,Second Affiliated Hospital,Zhejiang University School of Medicine;;Research progress of core biomarkers related to Alzheimer's disease[J];生命科学;2014-01
3 DU Yi-feng,YAN Peng,HAN Xiao-juan(Department of Neurology,Shandong Provincial Hospital,Jinan 250021,China);Study on the impairment of insulin signal transduction pathway in Alzheimer's disease[J];济宁医学院学报;2012-02
4 LIU Xiao-Jie, YANG Wei, QI Jin-Shun Department of Physiology, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan 030001, China;Oxidative stress and Alzheimer’s disease[J];生理学报;2012-01
5 Ai-Wu Xiao1, Jing He1, Qian Wang1,2, Yi Luo1, Yan Sun1, Yan-Ping Zhou1, Yang Guan3, Paul J. Lucassen2, Jia-Pei Dai1 1Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, China 2Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam 1098XH, the Netherlands 3Department of Ultrapathology, Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, China;The origin and development of plaques and phosphorylated tau are associated with axonopathy in Alzheimer’s disease[J];Neuroscience Bulletin;2011-05
6 ZHANG Jing-yan,WANG Rong*,ZHAO Jing-shu,JI Zhi-juan,ZHAO Zhi-wei,SHENG Shu-li(Central Laboratory,Beijing Geriatric Medical Research Center,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Xuanwu Hospital,Capital Medical University,Beijing 100053,China);Effects of P165 and rosiglitazone on the expression of IRS-1 andp-CREB in SH-SY5Y cell[J];首都医科大学学报;2011-04
7 JIANG Xin1*,XIE Ming1,BAI Li-juan1,CHEN Xiao-hong1,MA En-long2(1.Department of Neurology,The People's Hospital of Liaoning Province,Shenyang 110016,China;2.Department of Pharmacology,School of Pharmacy,ShenYang Pharmaceutical University,Shenyang 110016,China);Influences of peptidoglycan on PC12 cells after endocytosis of amyloid proteinβ oligomers in activated BV2 cells[J];首都医科大学学报;2011-04
8 ZHANG Xu1,2,WANG Rong1,2(1.Central Laboratory,Beijing Geriatric Medical Research Center,Xuanwu Hospital,Capital Medical University;2.Key Laboratory for Neurodegenerative Diseases,Ministry of Education;Rosiglitazone and Alzheimer's Disease[J];首都医科大学学报;2011-01
9 BAI Ying-ying,JIA Jian-ping(Department of Neurology,Xuanwu Hospital,Capital Medical University);Progresses in Studies on Molecular Genetics of Alzheimer's Disease[J];首都医科大学学报;2010-02
10 PENG Dan-tao, XU Xian-hao, MENG Xiao-mei, LIU Jiang-hong, XIE Yan-chen, FENG Kai(Department of Neurology, Beijing Hospital, Ministry of Health, Beijing 100730, China);Study of Plasma Levels of Aβ1-42,Aβ1-40 and p-tau(~(181)P) in Alzheimer Disease[J];中国神经免疫学和神经病学杂志;2005-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved