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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Increase of detection throughput of strand displacement amplification piezoelectric DNA sensors array

JIANG Tian lun, FU Wei ling,ZHANG Bo, LIU Ming hua, CHEN Ming, ZHANG Xue, ZHAO Shu ming, YU Fan, CHEN Xiao bin (Department of Clinical Laboratories, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To construct a strand displacement amplification (SDA) piezoelectric DNA sensor array with increased detection throughput. Methods Ten SDA piezoelectric DNA sensors were composed to build a SDA piezoelectric DNA sensor array (2×5) on a chip. The performance of SDA piezoelectric DNA sensor array was explored to detect Mycobacterium tuberculosis genomic fragment IS6110. Results Every micro sensor unit on the chip worked independently and had no interference with each other. Conclusion It is confirmed that SDA piezoelectric DNA sensor array can improve the detection throughput of SDA piezoelectric DNA sensor in some degree with the sensor's performance intact.
【Fund】: 国家“九五”科技攻关项目 ( 96 A2 3 0 4 0 4 );; 国家自然科学基金资助面上项目 ( 39870 831 );; 国家高技术计划生物技术领域青年基金资助项目 (“86 3”项目 ;; 全军“九五”医学科研计划资助面上项目( 98MO94 ;; 全军“十五”医学科研计划资助面上项目 ( 0 1MA1
【CateGory Index】: R197.39
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