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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Experimental study of gene therapy for Parkinson's disease with GAP-43 and TH genes

LIU Jun, ZHANG Ke cheng, CAI Wen qin (Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037,China)  
Objective To explore the role of growth associtated protein(GAP 43 ) gene and throsine hydroxylase(TH) gene in the treatment of Parkinson's disease(PD) by using the ex vivo gene transfer cells. Method After the construction of GAP 43 gene and TH gene in the retroviral vectors, the astrocytes were cultured with the supernatants containing different recombinant DNA and then were transplanted into the cerebrum of PD rats. The reduction of the rat rotation behavior was evaluated. Results PD rats received TH gene and TH/GAP 43 gene treatment revealed decreasing rotation, but GAP 43 gene treatment group did not. Conclusion TH gene exerts an obvious efficiency on the treatment of PD and GAP 43 gene can enhance the effect of TH gene.
【Fund】: 国家自然科学基金资助项目 (3 93 70 686)
【CateGory Index】: R742.5
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Chinese Journal Full-text Database 4 Hits
1 CHEN Yi,CHEN Biao~*(Beijing Geriatric Research Center,Xuanwu Hospital,Capital University of Medical Sciences,Beijing 100053,China);Advances in diagnostic technology for Parkinson's disease[J];Basic Medical Sciences and Clinics;2005-08
2 MA Jing-hong ZOU Hai-qiang,CHEN Biao~*(Dept.Neurology,Xuanwu Hospital of Capital University of Medical Sciences,Beijing 100053,China);DJ-1 gene and Parkinson disease[J];Basic & Clinical Medicine;2006-01
3 ZHANG Le,DUAN De-yi~*(School of Basic Medical Sciences,Capital University of Medical Sciences,Beijing 100054 China);Preclinical and Clinical Studies on Gene Therapy of Parkinson's Disease[J];Progress of Anatomical Sciences;2006-01
4 LUO Hai-yun,HE-Min (Dept. of Physiology of Kunming Medical College, Kunming 650031 );Mechanisms of Free Radical Causes Parkinson Disease among the Neurotoxic MPTP[J];Academic Journal of Kunming Medical College;2003-04
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