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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Relationship of zero-stress state and contents of several elements in aorta of alloxan-induced diabetic rats

ZHANG Xue liang, SHU Chang da, HE Jun (Department of Endocrinology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China)  
Objective To explore the relationship of zero stress state and the contents of several elements in the aorta in diabetic condition. Methods Contents of calcium(Ca), molybdenum(Mo), lithium(Li), manganese(Mn), cadmium(Cd), magnesium(Mg), lead(Pb), cobalt(Co), iron(Fe), copper(Cu), zinc(Zn), and chromium(Cr) in the aorta were determined with atomic absorption spectroscopy in diabetic rats induced by alloxan for 4 weeks and control rats. Zero stress state of aorta was observed by measuring the opening angle of aortic rings. Relationship of element contents in aorta with opening angle of aortic rings was analyzed in diabetic rats. Results Aortic Ca, Pb, Fe, Cu and Cr contents were significantly higher in diabetic rats than in control rats ( P 0.001). Opening angles of aortic ring were significantly higher in diabetic rats than in control rats ( P 0.01). Calcium content in the aorta had a positive correlation with the opening angle of aortic rings in diabetic rats ( r =0.762, P 0.01). Conclusion There is metabolic abnormality of Ca, Pb, Fe, Cu, and Cr, and the increase of Ca content has an effect on zero stress in the aorta of diabetic rats.
【CateGory Index】: R587.1
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