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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Effect of taurine and scoparoneon on cisplatin-induced cytosolic free [Ca~(2+) ]i overload in primary cultured rabbit proximal tubular cells

ZHOU Shi Wen, LIU Shi jie (Department of Clinical Pharmacology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China)  
Objective To study cisplatin induced cytosolic free [Ca 2+ ]i overload in primary culture of proximal tubular cells (PTC), and the preventing effect of taurine and scoparoneon in this event. Methods After proximal tubular cells (PTC) were isolated from New Zealand rabbits and cultured, some of them were incubated with cisplatin (0, 6.5, 13, 26, 52 μmol/L) for 24 h to induce cytosolic free [Ca 2+ ]. And others were cultured in the mediums with taurine or scoparoneon for 24 h, and then for another 24 h after cisplatin (26 μmol/L) addition. Cytosolic free [Ca 2+ ]i overload was measured with Fura 2/AM. Results ① Cisplatin (13, 26, 52 μmol/L) increased the concentration of Ca 2+ in PTC;②Taurine (1, 10 g/L) and scoparoneon (4, 8 mg/L) significantly decreased cisplatin induced cytosolic free i overload respectively. Conclusion Cisplatin can induce cytosolic free [Ca 2+ ]i overload in PTC, which can be prevented by taurine and scoparoneon.
【CateGory Index】: R965
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