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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Expressions of P16~(MTS1) and P27~(KIP1) in cholangiocarcinoma

LUO Kun lun, MA Kuan sheng, HE Zhen ping, WANG Shu guang, DONG Jia hong (Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To study the P16 MTS1 and P27 KIP1 expressions in human cholangiocarcinoma tissues and their relationship with clinical pathology. Methods The expressions of P16 MTS1 and P27 KIP1 were examined in 48 samples of cholangiocarcinoma tissues with pathological confirmation and 8 specimens of bile duct with chronic inflammation were determined with immunohistochemical method. Results The expression rates of P16 MTS1 and P27 KIP1 were 47.9% and 35.4% respectively in cancerous tissues, but 100% and 87.5% in normal bile duct tissues with chronic inflammation. The expressions of P16 MTS1 and P27 KIP1 had a significantly correlation with differentiation, lymph node or distant metastases, and clinical stage of cholangiocardinoma. Conclusion Our results suggest that aberrant expressions of P16 MTS1 and P27 KIP1 may be associated with the incidence and development of cholangiocarcinoma and can be regarded as prognostic markers.
【Fund】: 国家自然科学基金资助项目 (3 9770 72 7)
【CateGory Index】: R735.8
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【Co-references】
Chinese Journal Full-text Database 3 Hits
1 SI Wei ke*, GAO Li hong, LIU Bing, CHENG An, LI Peng, YAO JieDepartment of Clinical Biochemistry, the Third Military Medical University, Chongqing 400038, P.R.China;Regulation of G_1 Phase Cell Cycle Regulation Factors in Differentiation and Apoptosis of Matrine Induced Hepatoma Cells[J];Chinese Journal of Cancer;2001-08
2 HE Yu juan*,JIANG Ji kai,OU Yi heng,LIU Bei zhong,LIU Xiao shan,ZHANG Yan,MA Lin di,TU Zhi guangDepartment of Clinical Bio chemistry,Chongqing University of Medical Sciences,Chongqing 400016,P.R.China;Matrine Affects Early Expression ofProto-oncogenes in K562 Cells[J];Chinese Journal of Cancer;2002-04
3 CHEN Wei Zhong 1, LIN Yong 1, XIE Wei Fen 1, ZHANG Jun Ping 2, ZHANG Xin 3, CHENG Zhi Hong 3 (1. Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2.Department of Pharmacology, Colle;Regulation of telomerase activity and cell cycle by matrine in hepatoma cells in vitro[J];Academic Journal of Second Military Medical University;2002-05
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