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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Role of peritoneal fluid from endometriotic patients in their infertility

WANG Lin, SHI Chang xu (Department of Obstetrics and Gynecology, Southwest Hospital, Third Military University, Chongqing 400038,China)  
Objective To determine whether peritoneal fluid from women with endometriosis (EM) contributes to their infertility due to sperm function impairment and explore the role of IL 1β in the fluid in the event. Methods Infertile women with laparoscopy proved EM ( n =20) were subjected and fertile women without EM ( n =10) served as controls. Peritoneal fluid was aspirated from them. Sperm acrosome reaction was assessed following incubation with peritoneal fluid. The levels of IL 1β in peritoneal fluid from 15 infertile women with EM were determined with radioimmunoassay. Results Sperm acrosome reaction in EM group was reduced significantly in comparison with the control 16 h after incubation with peritoneal fluid. Peritoneal fluid IL 1β levels were (0.16±0.05) ng/ml (0.11 0.27 ng/ml) in women with EM and (0.06±0.28) ng/ml (0.0 0.16 ng/ml) in women without. Conclusion Peritoneal fluid from women with EM inhibits normal sperm acrosome reaction and increases the level of IL 1β in peritoneal fluid, which may be related to endometriosis associated infertility.
【CateGory Index】: R711.71
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