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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Expression of transcription factor-κB and IκB system in renal glomerulus of chronic nephritis

WANG Hui ming, ZHU Miao zhen, ZHANG Jian guo, JIA Kun xia, XIAO Bing min (Department of Nephrology, Dapin Hospital, Third Military Medical University, Chongqing 400042, China)  
Objective To study the roles of nuclear factor κB(NF κB) and IκB system and the expression of monocyte chemoatractant protein 1 (MCP 1) in the pathogenesis of chronic nephritis (CN). Methods ABC immunohistochemitry was used to detect the expression of NF κB P65, inhibitory κBα(IκBα) and MCP 1 protein in renal glomerulus of CN and normal control. At the same time, the relation of the expressions of NF κB P65 and IκBα to MCP 1 expression, renal patological changes and function impairment was studied. Results Higher expression of NF κB P65 and MCP 1 but lower of IκBα was detected in CN than in normal control, that was most significant in mesangial proliferation glomerulus nephpritis(MsPGN).The number of positive cells expressing NF κB P65 and MCP 1 in glomerulus of CN showed a negative correlation with IκBα expression, and positive correlation with histological changes and functional impairment in CN. Conclusion NF κB may play an important role in the pathogenesis of CN, and the number of positive cells expressing NF κB P65/IκBα may be considered as a predictor for the progressive renal injury in CN.
【CateGory Index】: R692.31
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