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《Acta Academiae Medicine Militaris Tertiae》 2002-01
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Expression of VEGFR-2 in medulloblastoma of children

CHEN Li gang, LI Kai hui, ZHANG Ling li, QIN Shan, PIAO Yong xu, ZENG Fan jun, CHENG Lin (Department of Neurosurgery, General Hospital of Chengdu Command, Chengdu 610083)  
Objective To study the expression and clinical significance of vascular endothelial growth factor receptor 2 (VEGFR 2) in medulloblastoma of children. Methods A total of 84 children with pathologically proved medulloblastoma and having sound radio chemotherapy and follow up after operation were subjected and divided into group A, B and C by their survival rate of 3, 5 and 10 years. The expression of VEGFR 2 in the 84 resected samples was studied with labelled strepatavilin biotin method (LSAB). The data were analyzed with Cox's proportional hazard regression model. Results The positive rate of VEGFR 2 expression was 88.09% in the 84 children, and 100%, 88.89% and 55.33% respectively in group A, B and C ( P 0.01). Cox regression analysis showed that VEGFR 2 was an independent prognostic factor affecting survival rate and had a negative correlation with the prognosis of medulloblastoma. Conclusion VEGFR 2 expression can be one of the predictors for the prognosis of children medulloblastoma.
【CateGory Index】: R739.41
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【References】
Chinese Journal Full-text Database 2 Hits
1 Chen Ligang et alDepartment of Neurosurgery,Luzhou Medical College Hospital;EXPRESSION OF ERBB-2 IN MEDULLOBLASTOMA OF CHILDREN[J];Journal of Luzhou Medical College;2006-01
2 Chen Ligang Department of Neurosurgerg,the Affiliated Hospital of Luzhou Medical College;THE EXPRESSION OF CYCLIND_1 AND P16 IN MEDULLOBLASTOMAS OF CHILDREN[J];Journal of Luzhou Medical College;2007-06
【Citations】
Chinese Journal Full-text Database 2 Hits
1 CHEN Li-gang, ZENG Fan-jun, LU Ming, ZHANG Jian-min, YANG Li-bing, HUANG Mao-qing, CHENG Lin (Department of Neurosurgery, General Hospital of Chengdu Command, Chengdu 610083,China);Medulloblastoma in children and its microsurgical management[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-04
2 SONG Shumei, ZENG Li, WU Jian, et al. Beijing Institute for Cancer Research, Beijing Medical University, Beijing 100034;Cloning and monoclonal antibody preparation of VEGF receptor KDR extracellular Ⅴ~Ⅶ domain and KDR expression in carcinomas of different origins[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Cheng Hongwei,Feng Chunguo,Mao Boyong,et al The First Affiliated Hospital, Anhui Medical University, Hefei 230022;Expression of VEGF and KDR in medulloblastoma and its clinical significance[J];Anhui Medical Journal;2005-06
2 MA Gui xin, XIANG Feng gang\ (Department of Personnel Affairs, Qingdao University Medical College , Qingdao 266021, China)\;;THE EXPRESSION OF KDR IN LUNG CANCER AND ITS CLINICO-PATHOLOGICAL SIGNIFICANCE[J];Acta Acadimae Qingdao Umvesitatis;2003-03
3 XIANG Feng-gang, MA Gui-xin (Department of Pathology, Qingdao University Medical College, Qingdao 266021, China);;EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS Flt1 AND KDR IN PULMONARY CARCINOMA AND THEIR RELATIONSHIP WITH METASTASIS AND PROGNOSIS[J];Acta Acadimae Qingdao Umvesitatis;2004-01
4 WANG Rui-Ting,SHEN Xing-bin,MEI Ai-min(Department of Pharmacology,Chengde Medical college,Hebei Chengde 067000,China);RELATIONSHIP BETWEEN VEGF EXPRESSION AND BIOLOGICAL BEHAVIOUR OF CC[J];Journal of Chengde Medical College;2006-02
5 LUO Ling,WU Kai-nan(Department of General Surgery,the First Affiliated Hospital, Chongqing University of Medical Sciences,Chongqing 400016,China);Inhibitory effect of quercetin on breast cancer cell lines MDA-MB-435S and its mechanism[J];Chongqing Medical Journal;2005-12
6 ;Recent Advances in Relation of Vascular Endothelial Growth Factor and Sarcoma[J];China Comtemporary Medicine;2001-01
7 WANG Yuan, CHENG Shao jun (Center of Nuclear Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Expression of KDR in human bladder cancer cell T24 and in transplanted tumor tissue of SCID mice[J];Acta Academiae Medicine Militaris Tertiae;2002-08
8 WANG Yuan, CHENG Shao jun (Department of Nuclear Medicine, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Growth suppression effect of ~(131)I-labeled anti-KDR monoclonal antibody on tumor tissue of human bladder cancer subcutaneously implanted in SCID mice[J];Acta Academiae Medicinae Militaris Tertiae;2004-14
9 SHI Yanhua,YE Hong,GUAN Lihua,et al. Chengde Medical College, Hebei, Chengde 067000;The significance of VEGF Flk-1 expression in normal nucosa,adenoma and colorectal carcinoma[J];Hebei Medical Journal;2007-02
10 Cheng Hongwei *, Mao Boyong, Zhang Shangfu,Cheng Niang. *Department of Neurosurgery, The First Affiliated Hospital, WCUMS, Chengdu 610041, China;Expression of KDR in Medulloblastoma and Its Clinical Implication[J];Journal of West China University of Medical Sciences;2001-03
【Co-references】
Chinese Journal Full-text Database 6 Hits
1 CHEN Li Gang 1, QIN San 2, ZHANG Ling Li 2, ZENG Fan Jun 1, PIAO Yong Xu 1, YANG Li Bing 1, LUO Ke Shu 3 1Department of Neurosurgery, 3Department of Pathology, Chinese PLA General Hospital of Chengdu Command Area, Chengdu 61003;Expression of urokinase-type plasminogen activator in medulloblastoma of children[J];Journal of The Fourth Military Medical University;2002-02
2 CHEN Li-gɑng,ZENG Li,ZHANG Ling -li,et ɑl.(1 Departmant of Neurosurgery,Ge neral Hosptal of Chengdu Army,Chengdu 6 10083,China);Clinical Significance of PTEN Expression in Medulloblastoma of Children[J];West China Medical Journal;2002-01
3 Chen Ligang et alDepartment of Neurosurgery,Luzhou Medical College Hospital;EXPRESSION OF ERBB-2 IN MEDULLOBLASTOMA OF CHILDREN[J];Journal of Luzhou Medical College;2006-01
4 CHEN Ligang, CHENG Lin, ZENG Fanjun, LU Min, LUO Keshu, WANG Shengxian Department of Neurosurgery, Department of Pathology, General Hospital of Chengdu Military Command of PLA, Chengdu 610083, China;Expression of urokinase-type plasminogen activator receptor in medulloblastomas of children[J];Chinese Journal of Neurdsurgical Disease Research;2002-02
5 CHEN Ligang1 , PIAO Yongxu1 , QIN Shan , ZENG Fanjun1 , LU Min1 , LI Kaihiu11Department, of Neuroswgery, Chengdu Military General Hospital; 2 Department of Infection, Huaxi Hospital ofSichuan University, Chengdu 610083, China;Expression of Bcl-2 gene in children medulloblastomas[J];Chinese Journal of Neurdsurgical Disease Research;2002-04
6 Cheng Ligang, Zheng Fanjun, Lu Ming et al. Department of Neurosurgery, Chengdu General Hospital, Chengdu Command, PIA, Chengdu 610083;Mlcrosurgical Treatment of Medulloblastomas in Children (Report of 34 cases)[J];Chinese Journal of Clinical Neurosurgery;2000-01
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 Chen Ligang Department of Neurosurgerg,the Affiliated Hospital of Luzhou Medical College;THE EXPRESSION OF CYCLIND_1 AND P16 IN MEDULLOBLASTOMAS OF CHILDREN[J];Journal of Luzhou Medical College;2007-06
2 CHEN Ligang,ZHANG Ling,LI Dingjun,LIU Luotong,MING Yang,DONG Jinhu Department of Neurosurgery,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China;Relationship between prognosis and expression of C-Jun and C-Fos in children medulloblastoma[J];Chinese Journal of Neurosurgical Disease Research;2007-05
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