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《Acta Academiae Medicinae Militaris Tertiae》 2006-10
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Human lung-derived mesenchymal stem cells inhibit T lymphocyte proliferation

XIANG Ming-zhang1, JIANG Yao-guang2, WANG Hui-chun1, LIN Yi-dan2 (1Department of Thoracic Surgery, Xinqiao Hospital, Chongqing 400037; 2Thoracic and Cardiovascular Surgery Research Center, Institute of Surgery Research,Daping Hospital, Third Military Medical University, Chongqing 400042, China)  
Objective To investigate the immunoregulatory ability of human lung-derived mesenchymal stem cells (MSCs) on T cells. Methods MSCs were isolated and cultured from human fetal lung. The immune phenotype was tested by flow cytometry and T lymphocyte proliferation assessed by thymidine incorporation. Results HLA-DR, CD86, and CD80 were not expressed in human lung-derived mesenchymal stem cells. The proliferation of peripherial blood-derived T cells was suppressed and this suppression seemed dependent on the concentration of MSCs. Conclusion Human lung-derived MSCs have been proved to possess immunomodulatory ability.
【CateGory Index】: R392
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1 XIANG Ming-zhang,JIANG Yao-guang,WANG Hui-chun,et al.(1.Department of Thoracic Surgery,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;2.Thoracic Surgery Center of PLA,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Isolation and identification of fetal lung-derived mesenchymal stem cells in human[J];Chongqing Medicine;2006-06
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