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《Acta Academiae Medicinae Militaris Tertiae》 2006-10
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Changes of blood fentanyl concentration in rats during anhepatic phase treated by large dose of dexamethasone

HU Yu, TAO Guo-cai, YI Bin (Department of Anesthesiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To observe the changes of blood fentanyl concentration in rats during anhepatic phase by treatment of large dose of dexamethasone and to investigate the extrahepatic metabolism of fentanyl. Methods Thirty rats were randomly divided into 3 groups (n=10 in each group): normal control group (Group A), anhepatic phase group (Group B), anhepatic phase+dexamethasone treatment group (Group C). The hepatic portal of rats was dissociated and closed in Group B. In Group C, 20 mg/kg of dexamethasone was infused 1 h before the occlusion of hepatic portal. After intravenous injection of 20 μg/kg fentanyl each time, the blood samples were collected. The fentanyl blood concentration was analyzed by HPLC. Results The blood fentanyl concentration of anhepatic phase dropped more slowly in Group B than Group C (P0.01). There were no significant difference between Group C and Group A (P0.05). Conclusion The liver is the main organ for fentanyl metabolism. There is the extrahepatic metabolism for fentanyl and dexamethasone can enhance the extrahepatic metabolism of fentanyl.
【CateGory Index】: R614
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Yanwan (Zhang YW), Zhang Yi (Zhang Y), Hu Xiaoqin (Hu XQ) (Department of Anesthesiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037);Ionpair RPHPLC method for determination of fentanyl plasma concentration[J];CHINESE PHARMACEUTICAL JOURNAL;1998-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Bing qian, WANG Ji zhong, SUN Gui jin (Criminal Police Brigade, Lianyungang Public Security Bureau, Lianyungang 222002, China);The Distribution of Fentanyl in Chief Internal Organs of Rabbits[J];JOURNAL OF HUAIHAI INSTITUTE OF TECHNOLOGY;2002-04
2 ZOU Wen1,ZHOU Wen2*(1.School of Pharmacy Science,Shandong University,Jinan 250012,China;2.Qilu Hospital of Shandong University,Jinan 250012,China);Metabolic Drug Interactions[J];Food and Drug;2007-12
3 YANG Xiu-fen,LIAO Mei-chun,YANG Zi-ming,GAO Qian-qian(Department of Pharmacology,Faculty of Pharmacology,Guangxi Traditional Chinese Medical University,Nanning 530001,China);Influence of Dihydromyricetin on the Hypnotic Effects of Pentobarbital Sodium on Mice[J];Lishizhen Medicine and Materia Medica Research;2008-09
4 ZHANG Hong, FANG Yu, WANG Shu-jun, LI Ying (Central Laboratory,Tongji Hospital,Tongji University,Shanghai 200065,China);Determination of Concentration of Fentanyl in Human Plasma by HPLC[J];Journal of Tongji University (Medical Science);2005-01
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7 SHAO Yong-jun,YU Zhong-shan,DONG Ying,et al.(Chinese People's Public Security University,Beijing 100038,China);The progress on determination of Fentanyl in plasma[J];Forensic Science and Technology;2007-05
8 YOU Peijun Jining First People's Hospital,Shandong Jining 272011;Determination of Concentration of Fentanyl in Human Plasma by HPLC With 2-step Extraction[J];China Modern Doctor;2007-05
9 LIN Changfu,LIU Chunting,LI Wenzhi,LI Enyou(Dept of Anesthesiology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086);Determination of Concentration of Fentanyl in Human Plasma by HPLC With UV Detection[J];China Pharmacy;2001-05
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