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《Acta Academiae Medicinae Militaris Tertiae》 2006-10
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Role of Id2 in neuronal differentiation of SVZa neural stem cells

ZHANG Zhi-yuan, YANG Hui, LIU Shi-yong, HE Jia-quan, QIU Ke-jun, SONG Ye-chun (Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China)  
Objective To investigate the role of Id2 in the neuronal differentiation of SVZa neural stem cells. Methods The neural stem cells derived from SVZa of postnatal day 0 (P0) Kunming mouse were separated and cultured in vitro. The rate of neuron in the differentiated cells of SVZa NSCs induced by sense Id2 or anntisense Id2 plasmids was detected by flow cytometry. The expression of Id2 in SVZa NSCs induced with different concentrations of BMP2 was detected by Western blotting. Results The rate of neuron of sense Id2 group was lower than that of blank group, while the rate of neuron in antisense Id2 group was higher than that of blank group. The expression of Id2 was enhanced by BMP2 in SVZa neural stem cells. Conclusion Id2 retards the neuronal differentiation of SVZa NSCs. The expression of Id2 is enhanced by BMP2. They are coordinately implicated in regulating the differentiation of SVZa NSCs to neurons.
【Fund】: 国家自然科学基金资助重点项目(30130110)~~
【CateGory Index】: R329
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Zhi yuan, YANG Hui, LIU Shi yong, HE Jia quan, WANG Bin, ZHANG Ke cheng (Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Roles of BMP2 in the differentiation of the neural stem cells of SVZa[J];Acta Academiae Medicinae Militaris Tertiae;2003-20
2 ZHANG Qingyong ,YANG Bo ,ZHAO Xinli , HE Wei ,SONG Laijun ,LI Hongwei ,FENG Zuyin , WANG Shukai1 ) Department of Thoracic Surgery, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450003 2 ) Department of Neurosurgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 3 ) Department of Physilogy, Zhengzhou University, Zhengzhou 450052;Culture and identification of embryonic rat neural stem cells[J];Journal of Henan Medical University;2003-01
【Co-citations】
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1 CHEN Jin-hua,YANG Hui,YIN Chang-lin,ZHANG Zhi-yuan,LIU Shi-yong,HE Jia-quan,GAO Fang-you(Department of Neurosurgery,Xinqiao Hospital,Third Millitary Medical University,Chongqing 400037,China);Role of BMP2 in differentiation of neural stem cells from anterior subventricular zone into GABAergic neurons[J];Acta Academiae Medicinae Militaris Tertiae;2007-08
2 LIU Sheng-hua, ZHOU Zheng, YANG Hui, LIU Jun, YIN Jin-bo, XIN Zhi-cheng (Department of Neurosurgery, Xinqiao Hospital, Third Millitary Medical University, Chongqing 400037, China);Effects of BMP-2 on dopaminergic neuronal differentiation of neural stem cells from SVZa and on DLX5 expression[J];Acta Academiae Medicinae Militaris Tertiae;2009-06
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Chinese Journal Full-text Database 10 Hits
1 TANG Wei,WANG Jian,HU Jian-peng,CHEN Ye-nong,HAN Xiao-xiang,CHENG Hong,YU Li-hua(Beijing University of Traditional Chinese Medicine,Beijing 100029,China);Comparison Naoluoxintong Serum Supplementation with Fetal Bovine Serum Supplementation in Inducing Differentiation of Rat Embryonic Neural Stem Cells[J];Journal of Anhui Traditional Chinese Medical College;2006-02
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