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《Acta Academiae Medicinae Militaris Tertiae》 2006-10
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Clinical application of non-bioartificial liver to patients with chronic severe hepatitis

XIANG De-dong, WANG Yu-ming, MAO Qing, ZHANG Xu-qing, MA Qiao-yu (Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To evaluate the therapeutic efficacy and safety of non-bioartificial liver in treating the patients with chronic severe hepatitis at early, middle and late stage. Methods A total of 132 patients with chronic severe hepatitis received treatment of non-bioartificial liver. Before and after the therapy, liver function, renal function, blood routine test, prothrombin activity (PTa), blood amine were analyzed. Symptoms and signs of all patients were observed closely. The survival rates of patients underwent non-bioartificial liver treatment were investigated. Results After the treatment of non-bioartificial liver, the symptoms and manifestation of patients improved. Serum total bilirubin (TB), alanine amino-transferase (ALT) and blood amine decreased. PTa increased significantly (P0.01). The side effects were very limited. The survival rates of patients with chronic severe hepatitis at early, middle and late stage were 90.0%, 50.3%, 14.9%, respectively. Conclusion The non-bioartificial liver is an effective means for chronic severe hepatitis, especially at early stage and middle stage.
【CateGory Index】: R575.1
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