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《Acta Academiae Medicinae Militaris Tertiae》 2006-13
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Effects of endotoxin preconditioning on NOS activity in rat brain after global brain ischemia/reperfusion

XIANG Qiang~1,WEN Liang~1,GAO Qiang-guo~2,LIU Ming-hua~1 (~1Department of Emergency,Southwest Hospital,~2Department of Cell Biology,College of Medicine,Third Military Medical University,Chongqing 400038,China)  
Objective To determine the effects and significance of endotoxin preconditioning on iNOS activity,nNOS activity in rat cerebral cortex,hippocampus and cerebella region after global brain ischemia/reperfusion.Methods Global ischemia for 20 min was made by four-vessel occlusion model(4-vo) in 60 Wistar rats,among which 30 were injected of 20 μg/kg MPL through caudal vein 24 h before model establishment.Another 8 rats undergoing sham operation served as controls.The dynamic change of iNOS activity,nNOS activity and neuron density of the cerebral cortex,hippocampus and cerebella region were observed at 1,4,8 h after reperfusion. Results The activity of iNOS and nNOS decreased significantly after endotoxin preconditioning in the regions mentioned above,as compared with that of rats only undergoing the ischemia/reperfusion.The neuron number in rat hippocampus decreased after ischemia/reperfusion,but no significant difference was found between control and endotoxin preconditioning groups.Conclusion The activity of iNOS and nNOS changed significantly after global brain ischemia/reperfusion.That endotoxin preconditioning decreased iNOS and nNOS activities may be the protective mechanism.
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 2 Hits
1 GAO Yi-lu1,LIU Zhi-guo1,SHEN Jian-hong1,LU Guang-ming2,ZHANG Tian-yi3(1Department of Neurosurgery,The Affiliated Hospital,2Department of Anatomy,3Department of Electron Microscope,Nantong University,Nantong 226001,China);Effect of normal saline of different temperature on morphological changes and NOS expression of spinal cord[J];Acta Academiae Medicinae Militaris Tertiae;2007-24
2 YU Wan-gui,DENG De-ming ( Medical School of Yangtze University,Jingzhou 434000,China)CHENG Ting-xuan (Department of Pathology,the First Hospital of Yangtze University,Jingzhou 434000,China)ZHANG Hen-wen,ZHANG Yang-xiang,ZHANG Dao-ming,et al ( Medical School of Yangtze University,Jingzhou 434000,China);Effect of Liensinine on NOS and C-Fos Protein Expression on Focal Cerebral Ischemia-Reperfusion Injury in Rats[J];Journal of Yangtze University(Natural Science Edition)Medicine V;2007-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YU Wan-gui,ZHANG Dao-ming,LIU-Lian,HUANG Xian-ju,HE Shang-rong,DENG De-ming (Medical School of Yangtze University,Jingzhou 434000,China);The Protective Effect of Liensinine on the Rats with focal cerebral ischemia[J];Journal of Yangtze University(Natural Science Edition);2006-09
2 DAI Wei-Guo, ZHU Wang-Dong, MA Chang-Sheng, MA Wen-Ling, YANG Tian-Zhu (Department of Anatomy, Handan Medical College, Handan 056029, China);Postnatal distribution and development of nitric oxide synthase positive neurons of corpus striatum in rats[J];Chinese Journal of Anatomy;2003-06
3 BAO Zheng-fu,XU Wei(Dept.of Neurosurgery,The 2nd Affiliated Hospital of Kunming Medical College,Kunming 650101,China);The Present Condition and Progresses of Hypothermia Brain Protection[J];Journal of Kunming Medical College;2007-01
4 Liu Jianping, Tang Weijun, Wu Jun, Lu Ping, Chen Yanbing (Medical Department, Affiliated Hospital, Chenzhou Medical College, Chenzhou 423000, China);Protective effect of neferine on ischemic brain damage induced by photochemistry[J];Chinese Journal of Clinical Pharmacy;2002-05
5 Luo Pifu, Xie Yao, Yao Zhibin, Chen Yici, Kuang Guobi (Department of Anatomy, Sun Yat-sen University of Medical Sciences, Guangzhou );EXPRESSION OF c-fos PROTOONCOGENE PROTEIN (FOS) IN THE RAT BRAIN INDUCED BY TRANSIENT GLOBAL CEREBRAL ISCHEMIA[J];Chinese Journal of Neuroanatomy;1993-01
6 Lei Deliang 1, Luo Xuegang 1, Peter R. Mouton 2, Donald K. Ingram 2 ( 1Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013; 2National Institute of Health, Gerontology Research Center, Baltimore, MD, USA);ABERRANT DISTRIBUTION OF ACTIVITY OF NEURONAL NITRIC OXIDE SYNTHASE IN THE CORTEX AND HIPPOCAMPUS OF APP/PS1 DOUBLE TRANSGENIC MICE[J];Chinese Journal of Neuroanatomy;2004-04
7 XU Jun-ying,PENG Jia-lin,WANG Jia-ling(Department of Pharmacology,Tongji Medical College of Huazhong University of Science and Technology,Hubei Wuhan 430030,China);Protective effect of isoliensinine on experimental cerebral ischemia injury[J];Chinese Journal of Hospital Pharmacy;2005-11
8 JIANG Ji-yao,XU Wei,YANG Peng-fan,et al.Department of Neurosurger y,Renji Hospi-tal,Shanghai Second Medical University,Shanghai200001,C hina;The duration of selective cerebral ultraprofound hypothermia following both carotid arteries clip in mon key[J];Chinese Journal of Neurosurgery;2003-04
9 QIN Hua-ping MEI Guang-hai WEI Liang Department of Neurosurgery Reji Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai 200127,China;Effect of profound hypothermia on early transcriptional changes of hippocampus after global ischemia in rats[J];Chinese Journal of Neurosurgery;2006-11
10 CHI Da ming,ZHU Yue,BAI Xi zhuang,et al.Department of Orthopedics,The First Affiliated Hospital,China Medical University,Shenyang 110001,China;Expression and significance of nitric oxide synthase in the process of closed femoral fracture healing of rats[J];Chinese Journal of Experimental Surgery;2004-06
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 LI Juan,XIA Yan-bin (College of Food Science and Technology,Hunan Agricultural University,Changsha 410128,China);Research progress on healthy function with alkaloid in embryo of lotus seed[J];Cereals & Oils;2010-01
2 QIU Zhao-juan1,ZHU Xuan-xuan1,DA Qing-guo1,WU Xu-tong1-ZHU Wu-yuan2(1.Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjiang 210029,Jiangsu,China; 2.Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China);Effect of Huayu Tongluo Fang on the Expression of ROS and NOS in Brain Tissue During the Reperfusion After Middle Cerebral Artery Occlusion in Rats[J];Chinese Archives of Traditional Chinese Medicine;2011-03
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