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《Acta Academiae Medicinae Militaris Tertiae》 2006-13
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Recombinant human growth hormone in repairing articular cartilage defects

DONG Wei-qiang,BAI Bo,CHEN Yi,YU Nan-sheng(Department of Orthopaedics,The First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China)  
Objective To investigate the mechanism of recombinant human growth hormone(rhGH) in articular cartilage defect repair in vivo.Methods The cylindrical,full-thick articular cartilage defects,(3.5 mm) in diameter,were made in the knee joints of 25 rabbits.rhGH of 0.1 U/kg was injected into the right knee joints 3 times a week for 4 weeks and equal volume of physiological saline to the left knee joints as control.The animals were killed respectively in 4,6,8,12,24 weeks,and the macroscopic,histologic and ultrastractural examinations were performed.Results The repairing process in experimental group was faster and better than that in the control.In the experimental groups,the defect was filled on week 4,the regenerated cartilage mainly in the shallow region and fibrous tissue in the deep region;on week 24,the regenerated tissue was morphologically close to the neighbour normal cartilage,hard to differentiate by macroscopy;Light microscopy showed the defect recovered to normal cartilage structure and the electron microscopy showed a large quantity of mature cartilage cells.In the control groups,the defect was of shallow introcession,mainly of fibrous tissue.The histological examination showed the significant difference between experimental and control groups(P0.01),except for the results on week 4.The regenerated cartilage got thinner on week 24,thinner than normal cartilage in 3 cases,close to normal cartilage without fissuration in 2 cases.Conclusion rhGH plays an important role in cartilage metabolism,effectively facilitates the repair of articular cartilage defect and provides a new non-traumatic method for the treatment of articular cartilage defects.
【CateGory Index】: R684
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Chinese Journal Full-text Database 3 Hits
1 WANG Li-gang, LI Yong, CHEN Wei-gao (Department of Orthopaedic,The Second Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China);The Effects of Chinese Traditional Medicine Pilose Antler Growth Factor on Rabbit Chondrocytes Proliferation[J];Acta Academiae Medicinae Jiangxi;2004-02
2 MENG Wei-chun, Dong Qi-rong (Department of Orthopaedics,The Second Hospital Affiliated to Suzhou University,Suzhou 215004,China);The Observation of the Histomorphology of Loaded Articular Cartilage[J];Acta Academiae Medicinae Suzhou;2002-04
3 LIU Gang, HU Yun-yu, MA Ping, et al. Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China;Biological effects of basic fibroblast growth factor and insulin-like growth factor-1 on cultured articular chondrocyes in rabbits[J];Chinese Journal of Traumatology;2003-04
Chinese Journal Full-text Database 10 Hits
2 SU Xin, DAI Xin-yi, ZHANG Yao-juan1, ZHANG Hong-wei* (Department of Plastic & Burn Surgery, the First Affiliated Hospital of NJMU, Nanjing 210029; 1Department of Pathogenic Biology, NJMU, Nanjing 210029, China);Effects of basic fibroblast growth factor and insuline-like growth factor-Ⅰ on the expression of typeⅡ collagen in cultured rabbit articular chondrocytes in vitro[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2006-05
3 KANG Si-ning,LIU Qiang(The First Clinical Hospital of Shanxi Medical University,Taiyuan 030001,China);Experimental study on effects of sodium hyaluronate and bFGF on repairing full-thickness articular cartilage defects of the rabbits' knees[J];Food and Drug;2006-02
4 SUN An-ke, PEI Guo-xian, LI Xiang-ping, et al.(Centre of Orthopaedics Traumatology of PLA, Nan Fang Hospital, The First Military Medical University, Guangzhou 510515, China);The requirements for cartilage tissue engineering in laryngeal and tracheal repair and reconstruction[J];Chinese Journal of Otorhinolaryngology-skull Base Surgery;2004-04
5 YUAN Puwei1 HUO Xijing1 ZHOU Haizhe3 YIN Jichao2LIU Deyu2 YANG Pinglin1 WANG Guoysu1 1Department of Orthopeadics, Second Hospital of Xi'an Jiaotong University , Xi'an 710004,China 2Xian Red Cross Hospital3Shanxi College of TCM;Effect of Gufusheng Capsule on IGF-1 of Rabbits with Steroid-induced Avascular Necrosis of Femoral Head[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2007-02
6 HOU Zhan-jiang, YAN Jing-long, FU Hai-liang, et al. Spine and Joint Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;Expression of basic fibroblast growth factor in ectopic osteogenesis of autogenetic minimal morselized bone[J];Chinese Journal of Trauma;2003-12
7 DAI Fei, WU Jun, XU Jian-zhong, WANG Xu-quan, CHEN Xi-wei, HE Wei-feng. Department of Orthopaedics, Orthopedic Center of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China;Gene modified human bone marrow derived mesenchymal stem cells xenotransplanted as seed cells in bone tissue engineering[J];Chinese Journal of Trauma;2005-11
8 KANG Si-ning, LIU Qiang. Department of Orthopedics, the First Affiliated Hospital of Shanxi Medical University 030001, China;An experimental study on intraarticular injection of exogenous basic fibroblast growth factor and hyaluronic acid to prevent osteoarthritis following knee injury in rabbits[J];Chinese Journal of Joint Surgery(Electronic Version);2007-01
9 ZHAO Guo-qiang, WANG Ning, LIU Rui. Department of Orthopedics Sur gery, Children's Hospital of Zhengjiang University, Hangzhou 310003, China;Insulin-like growth factor 1 in developmenta l dislocation of hip with avascular necrosis of femur head[J];Chinese Journal of Pediatric Surgery;2005-08
10 YE Chuan, DENG Zhansheng, LI Baojun, et al. Department of Orthopedics, Xiangya Hospital of Central South University, Changsha Hunan, 410008, P.R.China.;EFFECT OF THREE GROWTH FACTORS ON PROLIFERATION AND CELL PHENOTYPE OF HUMAN FETAL MENISCAL CELLS[J];Chinese Journal of Reparative and Reconstructive Surgery;2007-10
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Guo Yingjie; Zhou Qiuli; Liu Ping; Wang Ying; Fang Jinrong; Wang Benxiang(Research Centre of New Drug, Changchun College of Traditional Chinese Medicine (Changchun 130021 );The Research of Pilose Antler Polypeptides Promoting Osteoblast Precursor Cells and Chondrocytes Proliferation[J];CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS;1998-02
2 Chen Fulin , Mao Tianqiu , Feng Xue ,et al. College of Stomatology, the Fourth Military Medical University, Xi' an 710032;Isolation,purification and identification of rabbit joint cartilage cell in vitro[J];Journal of Modern Stomatology;1998-04
3 WENG Liang 1, ZHOU Qiu-li 2, WANG Li-juan 1, LIU Yong-qiang 1, WANG Yan 1, WANG Ying 1, WANG Ben-xiang 1 (1. New Drug Research Center, Changchun College of Traditional Chinese Medicine, Changchun 130021, China; 2. Institute of Biological Engin;VELVET ANTLER POLYPEPTIDES PROMOTED PROLIFERATION OF EPIDERMIC CELLS AND FIBROBLASTS AND SKIN WOUND HEALING[J];Acta Pharmaceutica Sinica;2001-11
4 SONG Hongxing *, LI Fobao, LIU Miao, et al. * Department of Orthopaedics, the First Affiliated Hospital, Sun Yat sen University of Medical Sciences, Guangzhou 510080, China;Effect of insulin-like growth factor-Ⅰ on the repair of articular cartilage defects[J];Chinese Journal of Traumatology;2001-11
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