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《Acta Academiae Medicinae Militaris Tertiae》 2006-13
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Peri-operative protein A immunoadsorption in sensitized renal transplant recipients:a case report and literature review

CHEN Hao,NIE Hai-bo,HU Wei-lie,ZHU Yun-song,ZHAO Yong-bin,ZHANG Xiao-ming,XIAO Yuan-song(Department of Urology,Guangzhou General Hospital,Guangzhou Military Command Area,Guangzhou 510010,China)  
Objective Recipients with high levels of panel reactive antibodies(PRA) are at increased risk of early immunologic graft loss.We study the protein A immunoadsorption(IA) in one patient and review literatures to investigate its effect and safety.Methods A re-transplanted recipient was treated with protein A IA before transplantation and during the early post-transplantation period.Literatures were reviewed to evaluate the effect of this therapy.Results Sixty-six high levels of PRA (range 30%-100%) recipients,after treated with IA(protein A) immediately before transplantation and during the early post-transplantation period,IgG,IgM,IgA were decreased and PRA was decreased to postoperative 30%.Sixty-five patients received a successful transplantation.Conclusion Protein A IA and anti-lymphocyte antibody therapy might be an effective and safe therapeutic strategy for the highly sensitized patients awaiting renal transplantation.The treatment can prevent early graft failure and increase the graft survival in the recipients.
【CateGory Index】: R699
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