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《Acta Academiae Medicinae Militaris Tertiae》 2006-13
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Effects of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholesterolemic patients

XUE Hong~(1),FU Chun-jiang~(2),WANG Xu-kai~(2),YANG Cheng-ming~(2),WANG Hong-yong~(2),ZHANG Ye~(2)(~1Department of Internal Medicine,Chongqing Public Security Fire Corps Hospital,Chongqing 400013,~2Department of Cardiology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To study the effect of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholestrolemic patients.Methods Totally 128 hypercholestrolemic patients were randomized to receive atorvastatin(10 mg/d,qn,n=64) or simvastatin as control(20 mg/d,qn,n=64).Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4-and 8-week treatment respectively.The changes of brachial artery internal diameter under reactive hyperemia situation or after taking nitroglycerin(500 μg) were respectively evaluated by B-mode ultrasonography.Results The effects of atorvastatin in lowering serum total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) levels were the same as simvastatin.The changes of brachial artery internal diameter under reactive hyperemia situation and after taking nitroglycerin(500 μg) in hypercholestrolemic patients were significantly increased after treatment.Conclusion Atorvastatin could decrease the serum level of TC,LDL-C and TG and improve the brachial artery endothelial function,and its effects were similar to simvastatin.
【CateGory Index】: R589.2
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1 SHEN Xing1,YU Geng-sheng1,TIAN Jie1,BAI Yong-hong2,ZHU Jing3,LIU Guan-xin3,CHEN Yuan1(1Department of Cardiovascular Diseases,2Department of Cardiac Ultrasonology,3Institute of Pediatrics,Children's Hospital of Chongqing Medical University,Chongqing 400014,China);Experimental studies of mesenchymal stem cells transplantation into rabbits with dilated cardiomyopathy[J];Acta Academiae Medicinae Militaris Tertiae;2008-12
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