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《Acta Academiae Medicinae Militaris Tertiae》 2006-13
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Effects of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholesterolemic patients

XUE Hong~(1),FU Chun-jiang~(2),WANG Xu-kai~(2),YANG Cheng-ming~(2),WANG Hong-yong~(2),ZHANG Ye~(2)(~1Department of Internal Medicine,Chongqing Public Security Fire Corps Hospital,Chongqing 400013,~2Department of Cardiology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To study the effect of atorvastatin on lipid profile modification and brachial artery endothelial function in hypercholestrolemic patients.Methods Totally 128 hypercholestrolemic patients were randomized to receive atorvastatin(10 mg/d,qn,n=64) or simvastatin as control(20 mg/d,qn,n=64).Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4-and 8-week treatment respectively.The changes of brachial artery internal diameter under reactive hyperemia situation or after taking nitroglycerin(500 μg) were respectively evaluated by B-mode ultrasonography.Results The effects of atorvastatin in lowering serum total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) levels were the same as simvastatin.The changes of brachial artery internal diameter under reactive hyperemia situation and after taking nitroglycerin(500 μg) in hypercholestrolemic patients were significantly increased after treatment.Conclusion Atorvastatin could decrease the serum level of TC,LDL-C and TG and improve the brachial artery endothelial function,and its effects were similar to simvastatin.
【CateGory Index】: R589.2
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Chinese Journal Full-text Database 1 Hits
1 LIANG Kun1),NIU Ying2),WEI Jinghan3)1)Ward 1 for Officers,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 2)Department of Cardiac and Nephrosis,Henan Provincial Corps Hospital,Chinese People's Armed Police Forces,Zhengzhou 450052 3)Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Effects of autologous endothelial progenitor cells transplantation plus atorvastatin treatment on acute myocardial infarction of rats[J];Journal of Zhengzhou University(Medical Sciences);2009-06
Chinese Journal Full-text Database 1 Hits
1 Li jiang , Zhao Shuiping , Li Xiangping , et al. Department of Cardiology, Second Affiliated Hospital , Hunan Medical University, Changsha 410011;Cholesterollowing therapy with simvastatin improves brachial endotheliumdependent relaxation[J];CHINESE JOURNAL OF CARDIOLOGY;1998-04
Chinese Journal Full-text Database 10 Hits
1 DAN San-li,LIN Run-ying,ZHOU Xiao-xia(Department of Internal Medicine,People′s Hospital,Sha Pingba District,Chongqing 400030,China);Effect of mental intervention on endothelial function of patients with coronary heart disease[J];Chongqing Medicine;2009-07
2 Qu Jianfeng,Liu Xiaodong,Liu Fenru,et alDepartment of Ultrasound,Xinyang Central Hospital,Henan 464000 China;Evaluation of Brachial Artery Endothelial Function in Patientswith Hyperlipidemia Using High-resolution Ultrasound[J];Chinese Journal of Ultrasound Diagnosis;2005-03
3 Wang Qiong,Zhao ChengruDepartment of Ultrasound,Jiexiu Municipal Hygiene School Hospital,Shanxi 032000 China;Effects of Vitamin C and Vitamin E on Endothelial Function in Hypertension Patients[J];Chinese Journal of Ultrasound Diagnosis;2006-12
4 ZHANG Xiang-yu , ZHAO Shui-ping, GAO Mei.Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, 410011,China;Endothelium-dependent and -independent Functions are Impaired in Patients With Dilated Cardiomyopathy[J];Journal of Chinese Physician;2003-09
5 od for the treatment of corneal ulceration.Corneal ulceration Amnio;Treatment Efficacy of Atorvastatin in Elderly Patients with Hyperlipidemia[J];Fujian Meidical Journal;2002-04
6 MO Xin ling,ZHAO Shui p ing, TANG Jian hua, et al.//Cardiovascular Department of Affiliated Hospital of Guilin Medical College,Guilin 541001,China;Detection of Endothelium-Dependent Vascular Relaxing Function in the Hypertensive Patients with Hypercholesterolemia[J];Acta Medicinae Sinica;2001-03
7 HE Yun,LI Zhi-xian,YANG Hong,et al Department of Diagnostic Ultrasound,1 stAffiliated Hospital of Guangxi Medical University,(Nanning 530021),China;Evaluation of brachial artery endothellal function in patients with diabetes mellitus by color doppler ultrasound[J];Guangxi Medical Journal;2004-02
8 CUI Bo,JIANG HongDept.of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effect of Atorvastatin on Endothelium-dependent Vasodilatation Function in Patients with Essential Hypertension Complicated by Hyperlipidemia[J];Medical Journal of Wuhan University;2006-06
9 SUN Jiu-bin,ZHANG Li,ZHOU Yin(Depantmant of Cardiology,The Harbin 242 Hospital,Harbin 150080,China);Curative Effects of Simvastatin on Left Ventricular Diastolic Dysfunction in Elderly Patients with Coronary Heart Disease[J];Heilongjiang Medical Journal;2006-08
10 ZHANG Huan-Yi,ZHOU Fa-Zhan,WANG Bo-Song,WANG Yong-Mei,LI Hui-Juan,and YIN Lu-Hua (Department of Cardiology,Tai'an Center Hospital,Tai'an 271000,China);Study of the Protect Function of Clopidogrel on Blood Vessel Endothelium in Patients with Coronary Heart Disease[J];Chinese Journal of Arteriosclerosis;2006-11
Chinese Journal Full-text Database 2 Hits
1 SHEN Xing1,YU Geng-sheng1,TIAN Jie1,BAI Yong-hong2,ZHU Jing3,LIU Guan-xin3,CHEN Yuan1(1Department of Cardiovascular Diseases,2Department of Cardiac Ultrasonology,3Institute of Pediatrics,Children's Hospital of Chongqing Medical University,Chongqing 400014,China);Experimental studies of mesenchymal stem cells transplantation into rabbits with dilated cardiomyopathy[J];Acta Academiae Medicinae Militaris Tertiae;2008-12
2 XIAO Yu-mei,YANG Jing-ning,MENG Ying-dong (Department of Geriatrics,Maoming People's Hospital,Maoming 525000,China);Comparison of atorvastatin and simvastatin in hypolipemic effect and atheromatous plaque resolution of carotid artery in senile patients with hyperlipemia[J];Journal of Guangdong Medical College;2006-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 WU Jie (School of Life Science and Chemical Engineering,Huaiyin Institute of Technology,Huai'an 223001);Synthesis of Bezafibrate by Phase Transfer Catalysis[J];Chinese Journal of Pharmaceuticals;2008-09
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