Expression and significance of KAI1/CD82 gene in non-small cell lung cancer
XU Xiao-jie,MEI Tong-hua(Department of Respiratory Diseases,The Second College of Clinical Medicine,Chongqing University of Medical Sciences,Chongqing 400010,China)
Objective To study the expression of KAI1/CD82 in non-small cell lung carcinomas(NSCLC) and explore the mechanism of invasion and metastasis of tumor cells.Methods The S-P immunohistochemistry was used to detect the expression of KAI1/CD82 in 62 specimens of primary NSCLC and 22 specimens of lymph node metastatic tissues. Twenty specimens from the normal tissues adjacent to the tumor over 5 cm were used as negative controls.Results The expression level of KAI1/CD82 in NSCLC(32.26%) was lower than that in negative control tissues(85.0%) (P0.01).KAI1/CD82 expression was low in the specimens of low differentiation,Ⅲ-Ⅳ stages,lymph node metastasis tumor(P0.05).The expression of KAI1/CD82 in lymph node metastasis of 22 cases was lower than that in primary focus(P0.05).Conclusion The decreased expression of KAI1/CD82 probably participates in malignant progression of NSCLC,and could be used an important index for invasion and metastasis of NSCLC.
【CateGory Index】： R734.2