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《Acta Academiae Medicinae Militaris Tertiae》 2006-21
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Effect of cervical sympathetic ganglia block on HPA axis in mice with combined radiation and burn injury and its related mechanisms

LU Jian-hua~1, TAO Jun~2, YE Jian-ning~3, SU Yong-ping~1, LI Hong-tao~1, CHENG Tian-min~1 (~1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Military Preventive Medicine, ~2Department of Anesthesiology, ~3Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, China)  
Objective To explore the roles of cervical sympathetic ganglia block(SB) in HPA axis of mice with combined radiation and burn injury and their related mechanisms. Methods Kunming mice were divided into control group, injury group (inflicted with 5 Gy irradiation and 15% TBSA full thickness burn injury), SB group (inflicted with combined injury, then treated daily by cervical SB). Serum GC, ACTH concentration and hippocampal NMDA receptor activity in each group were analyzed. In addition, another 20 Kunming mice (all injected intraperitoneally with enough MK-801) were divided into control (inflicted with combined radiation and burn injury) and SB group (inflicted with combined injury, then treated daily by cervical SB). Serum GC and ACTH concentration of these group were also detected. Results As compared with control group, serum GC, ACTH concentration and hippocampal NMDA receptor activity in injury group increased significantly. GC, ACTH concentration and NMDA receptor activity were higher than that of control group, but lower than that of injury group markedly. There were no significant differences of serum GC and ACTH concentration between injury group pretreated with MK-801 and SB group pretreated with MK-801. Conclusion By inhibiting NMDA receptor activity, SB promotes homeostatic restoration of HPA axis in mice of combined radiation and burn injury.
【Fund】: 国家重点基础研究发展规划资助项目(“973”项目)(G1999054201);; 海外青年学者合作研究基金资助项目(30328025);; 国家自然科学基金资助重点项目(30230360)~~
【CateGory Index】: R644
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