Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2006-21
Add to Favorite Get Latest Update

Expression of growth-associated protein in hippocampus of neonatal rats with hypoxic-ischemic brain damage

LU Li-qun, ZHAO Cong-min, PU Zhao-xia (Department of Pediatrics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China)  
Objective To observe the expression of growth-associated protein-43(GAP-43) in the hippocampus of neonatal rats with hypoxic-ischemic brain damage (HIBD). Methods HIBD was established by the method of Rice in 48 SD rats aged 7 days and another 48 matched normal rats served as control. Immunohistochemistry and RT-PCR were respectively used to detect the expression of GAP-43 protein and mRNA in all rat hippocampus on day 8, 10, 14, 21, 28, 35 after HIBD (n=8 at each time point for each group). Results The expression of GAP-43 protein and mRNA in hippocampus was obviously increased in HIBD rats as compared with normal rats, the peak of GAP-43 protein appeared at 3rd week, and the peak of mRNA at 2nd week. Conclusion The expression of GAP-43 protein and mRNA increased in the hippocampus of rats following HIBD, which was possibly related to the recovery of injured hippocampus.
【CateGory Index】: R722.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 ZHOU Yan, XIONG Ying, YUAN San-Ying. Department of Pediatrics, Second West China Hospital of Sichuan University, Chengdu 610041, China;Effect of tacrolimus on growth-associated protein-43 expression in the hippocampus of neonatal rats with hypoxic-ischemic brain damage[J];Chinese Journal of Contemporary Pediatrics;2009-01
2 JIA Tian-ming1,BAO Ru2,LIU Yu-feng3,DU Kai-xian1,GAN Bin1 (1.Department of Pediatrics,the Third Affiliated Hospital of Zhengzhou University;2.Department of Pediatrics,the Second Affliated Hospital of Zhengzhou University;3.Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Empirical Study on the Effect of Osmotic Opening of Blood Brain Barrier on the Facilitation of Nerve Growth Factor Passing[J];Journal of Applied Clinical Pediatrics;2008-06
【Co-references】
Chinese Journal Full-text Database 9 Hits
1 XU Si-yi, BAO Ying-hui, JIANG Ji-yao. Department of Neurosurgery, Renji Hospital, Shanghai Second Medical University, Shanghai 200127, China;Research progress of neurotrophic factors and blood-brain barrier[J];Chinese Journal of Neuromedicine;2005-01
2 Yu-Chun HUANG, Ying XIN, Yu-Kun HAN, Hong GAO Department of Neonatology, Dalian Children's Hospital, Dalian, Liaoning 116012, China; Department of Pediatrics, Second Hospital Affiliated to China Medical University, Shenyang 110004, China;Growth Associated Protein-43 mRNA Expression in Neonatal Rats with Hypoxic-Ischemic Brain Damaged[J];Chinese Journal of Contemporary Pediatrics;2003-02
3 Yan Bingchuan, Liu Heyu, Jia Tianming, et al. (Post-graduate of 2002 Grade, Zhengzhou University, Zhengzhou 450000, China);Experimental Study of the Protective Effect of Acupuncture on Hypoxic-Ischemic Brain Damage of Rats[J];Nervous Diseases and Mental Hygjene;2005-01
4 JIANG Xian-feng,SHI Wei,LIANG Jin (Department of Neurosurgery,The Affiliated Hospital of Medical College of Chinese People's Armed Police Force,Tianjin 300162,China);Studies on the effect of nerve growth factor on the expression of Bcl-2 and Bax of neuronal cell induced by oxyhemoglobin in mice[J];Acta Academiae Medicinae CPAPF;2006-06
5 Tie Lijun,Pan Jianping,Song Tianbao,et al Department of Pediatrics,First Hospital of Xi'an Jiaotong University,Xi'an 710061,China;The expression of GAP-43 in central nerve system of developing rats[J];Journal of Xi'an Medical University(Chinese);2001-06
6 Wang Juli, Han Yukun . Department of Peadiatrics, 2nd University Hospital, China Medical University, Shenyang, 110004;THE APOPTOTIC PERIOD OF NERVE CELLS AFTER HYPOXIC-ISCHEMIC BRAIN DAMAGE IN THE NEONATAL RAT[J];The Journal of Neonatology;2003-03
7 TIAN Mei~1,ZHAO Hong-gang~1,LI Dong-liang~1,et al (Department of Physiology and Neurobiology of Xinxiang Medical College, Henan Xinxiang 453003);Observation of hypoxia preconditioning inhibiting the apoptosis in neonatal rats with hypoxic-ischemic brain damage[J];Journal of Xinxiang Medical College;2005-06
8 MENG Ran,ZHOU Jin,WANG De sheng,et al.(Department of Neurology,The First Clinical College of Harbin Medical University,Harbin 150001,China);Study on mannitol osmotic opening blood-brain barrier by peripheral intravenous infusion[J];Journal of Apoplexy and Nervous Diseases;2003-04
9 YUAN Rong.WANG Chen-Hong,ZHANG Quan-Fu et al.Maternal and Children Hospital of Shenzhen City,Guangdong Province,Shenzhen 518028,China;The Expression of GAP-43mRNA in the Hippocampal Tissue of Fetal Rats Following Intrauterus Ischemia and Hypoxia[J];Maternal and Child Health Care of China;2006-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved