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《Acta Academiae Medicinae Militaris Tertiae》 2006-24
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Protective effect of combined NGF and ganglioside GM_1 on hypoxic-ischemic brain injury of newborn rats

HU Wei 1,ZHAO Cong-min 2,GONG Shou-ping 3(1Department of Pediatrics,General Hospital of Shaanxi Armed Police,Xi'an 710054;2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing 400037;3Department of Neurology,The Second Hospital of Xi'an Jiaotong University,Xi'an 710004,China)  
Objective To study the therapeutic effect of combined administration of nerve growth factor(NGF)and ganglioside GM_ 1 on the hypoxic-ischemic brain injury(HIBI)rat model and the relevant involving mechanisms.Methods A total of 120 7-day old rats were randomly divided into 5 groups:sham-operation group,HIBI group,NGF group,GM_ 1 group and NGF+GM_ 1 group.HE staining,immunohistochemical staining and TUNEL staining were employed respectively to study the morphological changes,bcl-2 and Bax expressions and apoptosis in the hippocampal neuron after treatment.Results Pathological changes were observed in the hippocampal neuron after HIBI.In NGF+GM_ 1 group,the level of Bcl-2 expression was increased significantly(P0.01),while that of Bax and the number of apoptotic cells in the hippocampal region were decreased significantly in comparison to the HIBI group(P0.01).Conclusion The combined administration of NGF and GM_ 1 may increase Bcl-2 expression and attenuate Bax expression,and thus inhibit the apoptosis in hippocampal region.
【Fund】: 陕西省2004年科技计划项目(2004K11-G9)~~
【CateGory Index】: R722.1
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