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《Acta Academiae Medicinae Militaris Tertiae》 2006-24
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Effects of vitamin A deficiency and its supplementation on tibial growth in rats

LIU Xing1,LI Ting-yu2,ZHANG De-wen1,MAO Chun-ting2(1Department of Orthopaedics,2Institute of Children Nutrition Children's Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China)  
Objective To study the effects of vitamin A deficiency(VAD)and its supplementation on the skeletal growth in rats.Methods Eighteen female Wistar rats were randomly divided into VAD(Vit A 400 IU/kg diet,n=3),supplement(n=9)and control groups(normal diet Vit A 6 500 IU/kg,n=6).The supplement groups were randomly divided into 3 sub-groups,and their diet was changed to Vit A 6 500 IU/kg diet from 14 d after pregnancy,0 d and 4 weeks after birth respectively until they were 7 weeks age old.When they were 0 day,4 and 7 weeks old,their body weight,the length of the tibia,serum Vit A level were measured,and the histology of growth plate was also observed.Results At every measuring times,the serum Vit A level was significantly lower,and the tibial length was shorter in VAD group than in the control(P0.01).For the tibial length,the pregnant and 0 d subgroups had kept up with the control until 7 weeks old,but that of the 4 weeks subgroup was still shorter than the control(P0.05),while longer than that of the VAD groups(P0.05).The histology of epiphyseal plate of the rats in VAD group showed disordered structure,and inhibited cartilage cell proliferation and calcification,with obviously reduced cell number,lesser and immature karyokinesis.Conclusion VAD has profound effect on the development of cartilage cells,and the earlier the supplement begins the more effective it will be.
【Fund】: 国家自然科学基金资助项目(30471462)~~
【CateGory Index】: R151
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