Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2006-24
Add to Favorite Get Latest Update

Relationship between changes of insulin and insulin receptor in hypothalamus and blood pressure in hypertensive rats

SHI Wei-bin,YANG Cheng-ming,LIU Guang-yao,WANG Xu-kai,FU Chun-jiang(Department of Cardiovascular Diseases,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To observe the changes of insulin and its receptor in hypothalamus of spontaneous hypertensive rats(SHR)and their relationship with blood pressure.Methods Thirty SHR and 30 Wistar rats matched with SHR respectively were randomly assigned to receive normal saline,0.02,0.2 pmol insulin.The concentration of insulin in hypothalamus,the B_ max and K_ D of insulin receptor in cellular membrane from hypothalamus in SHR and Wistar rats were investigated and the effect of insulin microinjection into anterior hypothalamic area on blood pressure were analysed.Results The insulin concentration in hypothalamus of SHR was higher than that in Wistar rats(P0.05),but the plasma insulin concentration was similar in both groups.The quantity of insulin receptor in the hypothalamus of SHR was less than that of Wistar rats but no difference of K_ D was found between the two groups.Microinjection of 0.2 pmol insulin into anterior hypothalamic area significantly decreased MAP in SHR in 1 h,but not in Wistar rats.Conclusion Insulin in hypothalamus may be a negative feedback to the high arterial pressure and has a protective effect against the continuous increase of arterial pressure during the development of hypertension.
【CateGory Index】: R544.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved