Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2006-24
Add to Favorite Get Latest Update

Effect of γ-ray radiation on cytokine levels in stored red blood cells

LI Ru-qing,JIANG Tian-lun,XIAO Rui-qing,REN De-hui,ZENG Jie,SHUAI Gui-zhen(Department of Blood Transfusion,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To study the effect of γ-ray radiation at different dose on the cytokine levels of IL-6,IL-8 and TNF-α in stored red blood cells and to determine the optimal γ-ray dose for preparing the stored blood.Methods The cytokine levels of IL-6,IL-8 and TNF-α in the stored blood were studied by ELISA immediately or in 1st,2nd,3rd,4th week after γ-ray irradiation at the dose of 15,20,25,30,35 Gy.Results The content of cytokines increased with prolonged storage time both in irradiated blood and control blood,more significantly in control blood,and to the stored blood of the same storage time,the levels of the cytokines in control blood were higher than those in irradiated blood(P0.05),but the levels of the cytokines in irradiated blood showed no significant changes when the irradiation dose was 25,30 and 35 Gy(P0.05).Conclusion The optimal irradiation dose for blood storage is 25 Gy.
【CateGory Index】: R457.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved