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《Acta Academiae Medicinae Militaris Tertiae》 2006-24
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Comparing inhibition effects of four antihistamines on chemokines and cytokines expression of cultured nasal polyps in vitro

PAN Hu,HAO Fei(Department of Dermatology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the inhibition effects of different antihistamines on the expressions of chemokines and cytokines released by nasal polyps in vitro.Methods The fresh nasal polyps resected under endoscope from the patients admitted to our hospital were cultured with mizolastine,cetirizine,loratadine,fexofenadine,dexamethasone,or ciclosporin A respectively for 24 h,with the addition of histamine and arachidonic acid.The total RNA of polyps was obtained and purified with tripure isolation reagent.The mRNA expression levels of monocyte chemoattractant protein-1(MCP-1),monocyte chemoattractant protein-3(MCP-3),regulated on activation,normal T cell expressed and secreted(RANTES),eotaxin were analyzed by RT-PCR.The concentrations of interleukin(IL)-4,IL-5 and tumor necrosis factor-α(TNF-α)in cultured supernatant was detected by ELISA.Results The MCP-1 mRNA expression in nasal polyps treated by mizolastine was weaker than those by loratadine and fexofenadine;the MCP-3 mRNA expression by mizolastine was weaker than those by cetirizine and loratadine;the RANTES mRNA expression by mizolastine was weaker than those by loratadine and fexofenadine;the eotaxin mRNA expression by mizolastine was weaker than that by cetirizine(all P0.05).The levels of IL-4 and IL-5 in supernatant by mizolastine was lower than those by cetirizine and loratadine,while the levels of TNF-α had no significant difference by all antihistamines.Conclusion Mizolastine can inhibit the expression of chemokines and cytokines more strongly than other antihistamines.
【CateGory Index】: R765
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1 LI Su;CHEN Jie;LI Bin;LI Fulun;MIAO Xiao;Yueyang Hospital Affiliated to Shanghai University of TCM;;Effect of Qinzhu Liangxue Mixture on Eczema in Peripheral Blood of Patients with GR Receptor Alpha[J];云南中医学院学报;2016-01
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