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《Acta Academiae Medicinae Militaris Tertiae》 2006-24
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A perspective study on growth and development of children with asymptomatic congenital cytomegalovirus infection in poverty-striken mountain areas

ZHANG Xin-wen,LI Fen,SHI Xiao-wei,YU Xue-wen,ZHANG Jian-ping,SHI Jian(Maternal and Child Health Center,The First Affiliated Hospital of Medical College,Xi'an Jiaotong University,Xi'an 710061,China)  
Objective To explore the physical and intellectual development of children with asymptomatic congenital human cytomegalovirus(HCMV)infection.Methods A total of 106 newborns whose mothers were infected with active HCMV during pregnancy were collected between October 1997 to October 2000 in southern poverty-striken mountain areas of Shaanxi province,including 34 neonates with asymptomatic congenital infection and 72 neonates without congenital infection.Another 106 newborns were used as control,whose mothers were without active HCMV infection during gestational period.Follow-up included physical development in neonatal and infant period,intellectual development in infant and pre-school period,hearing test in pre-school period.Results There was no significant difference between the asymptomatic congenital HCMV children or non-congenital HCMV children and the control children in average body weight,length,and head circumference.In infancy or pre-school period,the developmental and intellectual quotients of asymptomatic congenital HCMV children were all lower than that of the control children,especially in language behavior.Hearing dysplasia was more in asymptomatic HCMV children than that in the control children.Conclusion Congenital HCMV infection does not affect on physical development of asymptomatic congenital HCMV children,but affects on language and hearing capability of children in the future and can lead to obvious retardation of intellectual development.We should attach importance to the monitoring of long-term intellectual and hearing capability of asymptomatic HCMV children and carry out proper intervention to the children with language and hearing dysplasia.
【CateGory Index】: R725.1
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