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《Acta Academiae Medicinae Militaris Tertiae》 2006-24
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Expression of drug resistance-related genes in diffuse large B cell lymphoma and their clinical significance

XIE Jia-yin,WANG Dong,YANG Zhen-zhou,WANG Ge,XIANG De-bing(Department of Oncology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China)  
Objective To investigate the expression of drug resistance-related genes including p53,bcl-2,P-glycoprotein(P-gp),glutathione-S-transferase-π(GST-π)and DNA topoisomeraseⅡ(TopoⅡ)and their clinical significance in diffuse large B cell lymphomas(DLBCL).Methods Tissue samples from 34 DLBCL patients were immunohistochemically stained for p53,bcl-2,P-gp,GST-π and TopoⅡ.Results The positive expression rate of p53,bcl-2,P-gp,GST-π and TopoⅡin DLBCL was 32.4%,47.0%,25.2%,52.9% and 64.7% respectively.Patients with positive expression of p53,bcl-2,P-gp and GST-π had lower efficacy to chemotherapy and shorter overall survival at 3 years than patients with negative expression.However,the patients with positive expression of TopoⅡhad higher efficacy,but shorter overall survival at 3 years than the patients with negative expression.Conclusion The expressions of p53,bcl-2,P-gp,GST-π and TopoⅡcan be used as predictors of chemotherapeutic efficacy and survival of DLBCL patients,and provide guidance for individual therapy for DLBCL patients.
【Fund】: 重庆市自然科学基金资助项目(2004.BB5031)~~
【CateGory Index】: R733.1
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【Citations】
Chinese Journal Full-text Database 2 Hits
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【Co-citations】
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1 MA Yanchun, ZHAO Yagang, SUN Dayong. Department of Gastroenterology, General Hospital of Guangzhou Military Command of PLA, Guangzhou (510010);Expression of Runx3 in Different Gastric Mucosal Lesions and its Relationship with Helicobacter pylori Infection[J];胃肠病学;2013-01
2 YANG Hai-song,HUANG Jian-jun Department of Mastopathy,Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China;Effects of Neoadjuvant Chemotherapy on P-gp,GST-π Expression in Breast Cancer[J];肿瘤防治研究;2009-02
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7 XIE Jia-yin ,WANG Dong , XIANG De-bing ,et al. (Department of Oncology,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China; Department of Oncology,Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China);Research on relation of expression of drug resistance-related genes in diffuse large B cell lymphomas and clinical individualized chemotherapy[J];重庆医学;2007-02
8 XIE Jia-yin,WANG Dong,YANG Zhen-zhou,WANG Ge,XIANG De-bing(Department of Oncology,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Expression of drug resistance-related genes in diffuse large B cell lymphoma and their clinical significance[J];第三军医大学学报;2006-24
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