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《Acta Academiae Medicinae Militaris Tertiae》 2007-01
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Nordy on induced differentiation of HPV16 subgenes-immortalized human endocervical cells

ZHAO Jing~(1),ZHAO Yong~(1),BIAN Xiu-wu~(2)(~(1)Department of Pathophysiology,Chongqing Medical University,Chongqing 400016,~(2)Department of Pathology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the effects of Nordy on induced differentiation of HPV16 subgenes-immortalized human endocervical cells(H8 cells).Methods After treated with Nordy,the proliferation of H8 was tested with MTT assay.The effect of Nordy on cell cycle of H8 was analyzed by flow cytometer(FCM).The expression of Ki67 of H8 was detected by immunohistochemistry.The activity of telomerase was tested by TRAP-ELISA.Results Nordy could inhibit proliferation of H8 cells significantly.H8 cells were arrested in G_(0)/G_(1) phase after Nordy treatment.The Ki67 expression and telomerase activity reduced significantly after Nordy treatment.Conclusion Nordy could induce the differentiation of H8 cell lines by inhibiting their proliferation,blocking cell cycle and decreasing telomerase activity.
【Fund】: 重庆市科委攻关课题(2004-27-17)~~
【CateGory Index】: R737.33
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1 JIA Shi-jun1,ZHAO Yong1,BIAN Xiu-wu2( 1Department of Pathophysiology,College of Basic Medical Sciences,Chongqing Medical University,Chongqing 400016; 2Institute of Pathology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Effects of Nordy on proliferation,cell cycle and Aurora-A expression in human ovarian cancer cell lines 3AO and SKOV3[J];Acta Academiae Medicinae Militaris Tertiae;2009-18
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1 LU Jia you, BIAN Xiu wu (Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of chemotherapy and radiotherapy on activity and mRNA expression of DNMT in gliomas[J];Acta Academiae Medicinae Militaris Tertiae;2003-22
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