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《Acta Academiae Medicinae Militaris Tertiae》 2007-01
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Expression of NF-κB P65 in mouse to rat cardiac xenograft model

YANG Guang-lun,YAO Zhen-xiang,HUANG Ping,TU Gang(Department of General Surgery,The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)  
Objective To reproduce mouse to rat heart transplantation model and determine the expression and DNA binding activity of NF-κB P65 in xenograft heart.Methods Six NIH mice were used as heart donors and six Wistar rats as heart recipients.After the transplantation,the transplanted hearts without any drug intervention were prepared for experiment after cardiac arrest.The hearts from another six NIH mice served as normal controls.The expression of NF-κB P65 protein and NF-κB P65 DNA binding activity in xenograft heart were determined by Western blotting and electrophoretic mobility shift assay(EMSA).Results The expression level of NF-κB P65 and NF-κB P65 DNA binding activity in transplanted hearts were higher than control hearts(P0.05).Conclusion NF-κB may play an important role in mouse to rat heart transplantation.
【Fund】: 重庆市卫生局科研课题(05-2-180)~~
【CateGory Index】: R654.2
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【References】
Chinese Journal Full-text Database 2 Hits
1 YANG Guang-lun,YAO Zhen-xiang,HUANG Ping,TU Gang(Department of General Surgery,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Effect of leflunomide on NF-κB P65 in mouse to rat cardiac xenograft[J];Acta Academiae Medicinae Militaris Tertiae;2007-23
2 FENG Bing, YANG Xu, YE Zi-lin, YUAN Fa-huan, YANG Hui-biao, ZHANG Yao-quan(Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Expression changes of NF-κB in aorta of rats with chronic renal failure[J];Acta Academiae Medicinae Militaris Tertiae;2008-15
【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Guanglun,et al (Research Laboratory of Organ Transplantation,College of Clinical Medicine,Chongqing Medical University);Modified cuff technique for cardiac xenotransplantation in neck[J];Journal of Chongqing Medical University;2004-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 YANG Guang-lun,YAO Zhen-xiang,HUANG Ping,TU Gang(Department of General Surgery,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Effect of leflunomide on NF-κB P65 in mouse to rat cardiac xenograft[J];Acta Academiae Medicinae Militaris Tertiae;2007-23
2 YANG Guang-lun YAO Zhen-xiang HUANG Ping Department of General Surgery,The First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016,China;The expression of ICAM-1 in mouse to rat cardiac xenograft and the effects of leflunomide and cyclosporine[J];Chinese Journal of Organ Transplantation;2007-07
3 LAN Gang,et al (Department of Cardiothoracic Surgery,Southwest Hospital,the Third Military Medical University);Construction of heart heterotopic transplantation model in inbred strain rat[J];Journal of Chongqing Medical University;2006-04
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Chinese Journal Full-text Database 4 Hits
1 XU Zhi 1, WU Guo-ming 1, QIAN Gui-sheng 1, WANG Xing-sheng 1, CHEN Wei-zhong 1, LI Shu-ping 1, XUE Qiao 2, WANG Shi-wen 2 ( 1Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, 2Institute of Geratic Cardiology, General Hospital of PLA, Beijing 100853, China);Hypoxia enhances activation of NF-kappa B and induces TNF-α, IL-1β expression in rat monocytes[J];Acta Academiae Medicinae Militaris Tertiae;2006-08
2 HUANG Ping, YAO Zhenxiang. Research Laboratory of Organ Transplantation, Collegeof Clinical Medicine, Chongqing Medical University, Chongqing 400016, China;Prolonged xenograft survival by leflunomide in mouse-to-rat cardiac xenograft model[J];Chineae Journal of Organ Transplantation;2001-06
3 YE Yun jie, NI Zhao hui, QIAN Jia qi, HE Ying xin.Renal Division, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China;Relationship between microinflammation state of end stage renal disease and atherosclerosis[J];Chinese Journal of Nephrology;2004-03
4 YANG Guanglun,et al (Research Laboratory of Organ Transplantation,College of Clinical Medicine,Chongqing Medical University);Modified cuff technique for cardiac xenotransplantation in neck[J];Journal of Chongqing Medical University;2004-01
【Secondary Citations】
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1 HUANG Ping, et al (Research Laboratory of Organ Transplantation,Chongqing Medical University,400016);The establishment of the model for Mouse-to-rat heart transplantation.[J];Acta Universitatis Scientiae Medicinae;2001-01
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