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《Acta Academiae Medicinae Militaris Tertiae》 2007-01
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Tetracycline for lung volume reduction by fibrobronchoscope

DAI Xiao-tian,YANG He-ping,WANG Hai-jing,YI Bin,XIONG Wei,HU Ruo-lan,DUAN Hai-lin,SONG Jie(Department of Respiratory Diseases,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To investigate the possibility of tetracycline for lung volume reduction by fibrobronchoscope.Methods Five adult mongrel dogs were anesthetized and fibrobronchoscope was inserted to the subsegmental bronchi through mouth.CRE sacculus dilation catheter was put into local lung inflate sacculus.The suspension of 5% tetracycline was administered to anesthetized dogs.Atrophic constitution of local lung was detected by roentgenographic examination at 2~(nd),4~(th),8~(th),12~(th) week and type Ⅰ,Ⅱ collagens were detected by histopathologic methods at 12~(th) week after tetracycline application.Results Procedure of operation was successful without technical difficulty,no dogs dead and no complications happened.Lung tissue of high density was found at 12~(th) week by CT,but no inflammatory changes.Under microscope,scar tissue was seen,indicating obstructive tissues lost the normal lung structure and formed dense fibrous tissues.Type Ⅰ collagen was positive and type Ⅱ collagen was negtive in lung tissue.Conclusion Operative procedure through fibrobronchoscope to administer tetracycline is easy,with the advantages of less trauma,few complications so that it can be used in lung volume reduction.
【Fund】: 第三军医大学西南医院院管课题(2004)~~
【CateGory Index】: R655.3
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