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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Effects of cervical sympathetic ganglia block on GR expression and cytokine release of macrophage in mice with combined radiation and burn injury

LU Jian-hua 1,SU Yong-ping 1,TAO Jun 2,YE Jian-ning 3(1State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injurg,Colleg of Preventive Medicine,Chongqing 400038,2Department of Anesthesiology,3Department of Neurology,Xingiao Hospital Third Militnry Medical University,Chongqing 400037,China)  
Objective To explore the roles of cervical sympathetic ganglia block(SB)in glucocorticoid receptor(GR),protein levels and proinflammatory cytokine release of peritoneal macrophage in mice with combined radiation and burn injury.Methods Thirty-two Kunming mice were divided into control group,injury group(inflicted with 5 Gy irradiation and 15% TBSA full thickness burn injury),unilateral SB(inflicted with injury,treated daily by unilateral cervical SB)and bilateral SB group(inflicted with injury,treated daily by bilateral cervical SB).The roles of SB were evaluated by comparing GR protein levels and proinflammatory cytokine(TNF-α,IL-1β,IL-6)release of peritoneal macrophage in each group.Results Compared with control group,GR protein levels in injury group decreased significantly.The levels of unilateral SB and bilateral SB group were lower than that of control group but higher than that of injury group.Proinflammatory cytokine(TNF-α,IL-1β,IL-6)release in unilateral SB and bilateral SB groups was higher than that in control group but significantly lower than injury group.There were no significant differences of GR protein levels and proinflammatory cytokine(TNF-α,IL-1β,IL-6)release between unilateral SB and bilateral SB groups.Conclusion Bilateral SB and unilateral SB can be an effective therapeutic approach for ameliorating GR function and controlling inflammatory response of peritoneal macrophage following severe trauma.
【Fund】: 国家重点基础研究发展规划项目(“973”项目)(G1999054201);; 海外青年学者合作研究基金(30328025);; 国家自然科学基金重点项目(30230360)~~
【CateGory Index】: R644
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