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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Construction of goat tibial diaphyseal defect model by half-ring sulcated external fixator

JIAN Yue-kui,YANG Liu,LI Qi-hong,LIU Lei,GAO Chun-yang(Center for Joint Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To construct goat tibial diaphyseal defect model by using half-ring sulcated external fixator.Methods Nine goats were divided into three groups.The 20 percent single tibial diaphyseal defect of every goat was made and fixed with half-ring sulcated external fixator.Animals in each group were killed respectively at 5 th,10 th,15 th week postoperatively.Bone formation was evaluated by X-ray and histology.Results The fixity was stable in goat tibial diaphyseal defect.No bone repair was found at the 5 th,10 th,15 th week postoperatively and sclerization at the broken ends of the fractured bone was observed at the 15 th week postoperatively but no bone formation was found.Conclusion Half-ring sulcated external fixator is a fair apparatus in constructing long bone defect model for tissue engineering repairing study and 20 percent goat tibial diaphyseal defect cannot be repaired by itself.
【Fund】: 国家高技术研究发展计划重大攻关课题(“863”计划)(2003AA205020)~~
【CateGory Index】: R-332
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