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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Expression of glucose transporter type 1 in rat retina induced by hypoxia and taurine

CHEN Fang, MI Man-tian, BAI Xue, XU Hong-xia, CHEN Ka (Department of Nutrition and Food Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing Key Lab of Food Security and Nutrition Research, Chongqing 400038, China)  
Objective To explore the effect of taurine on glucose transporter type 1(GLUT-1)in rat retina and investigate the protection mechanism of taurine to hypoxia. Methods Ninety-six adult Sprague Dawley rats were divided into 6 groups randomly. The rats in control group (C) , 4 500-meter hypoxia group (45H)and 5 500-meter hypoxia group (55H) were fed with regular forage, while the rats in taurine group (T) , 4 500-meter hypoxia combining with taurine group (45HT)and 5 500-meter hypoxia with taurine group (55HT) were supplemented with forage containing 2.4% taurine for one week. Then rats of 45H, 45HT, 55H, and 55HT groups were put into low-pressure chamber in which air condition at 4 500-meter and 5 500-meter altitude was simulated respectively. On day 0, 1, 2, 3 after hypoxia, retinas were taken out to extract total RNA and protein. Expression of GLUT-1 in retina was determined by RT-PCR and Western blotting. Results The expression of GLUT-1 mRNA and protein in retina decreased on day 1 after hypoxia,(P0.05), began to rise on day 2, and mRNA returned to control level and protein expression overpassed control level on day 3. Taurine up-regulated the expression as compared with hypoxia groups. Conclusion Taurine will promote the adaptability adjustment of hypoxic retina through up-regulating GLUT-1 that keeps normal visual function in high-altitude hypoxia.
【Fund】: 全军医学科学技术研究“十一五”计划基金重点课题(06Z028)~~
【CateGory Index】: R774.1
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1 CHEN Fang,MI Man-tian,BAI Xue(Department of Nutrition and Food Hygiene,College of Preventive Medicine,Third Military Medical University, Chongqing 400038,China);Effects of taurine on high-altitude hypoxia induced changes of retina morphology and SDH,LDH activity[J];Acta Academiae Medicinae Militaris Tertiae;2006-06
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