Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2007-04
Add to Favorite Get Latest Update

Effect of low-dose cyclophosphamide on cell apoptosis of implanted human lung carcinoma in nude mice

SHENG Wei-li,MEI Tong-hua(Department of Respiratory Diseases,The Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China)  
Objective To explore the effect of low-dose cyclophosphamide(CTX)on apoptosis of implanted human lung carcinoma in nude mice.Methods BALB/c nude mice bearing lung carcinoma were randomized into several groups,each receiving different dose of CTX respectively.We investigated antitumor effect and toxicity of CTX.At the end of experiment,tumors were resected for immunohistochemical staining.Nuclear factor κB(NF-κB P65)was detected and apoptosis was measured by TUNEL.Morphological changes of tumor cells were observed.Results The volume of tumors was much smaller in mice receiving continuous low-dose CTX than that receiving maximally tolerated dose of CTX and normal saline(control group).The apoptotic index was increased and NF-κB P65 decreased in the mice receiving low-dose of CTX.Conclusion The continuous low-dose of CTX inhibits the growth of implanted tumor and increases tumor cell apoptosis,which may be due to the down-regulation of nuclear factor κB.
【Fund】: 重庆市卫生局资助项目(200453)~~
【CateGory Index】: R73-3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 YANG Liu qin, FANG Dian chun (Gastroenterology Research Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Effects of expressions of NF-κB and survivin on anti-tumor activity of TRAIL in gastric carcinoma cells[J];Acta Academiae Medicinae Militaris Tertiae;2004-07
2 LIU Dong-yu, KONG Jing, LIU Feng-yi, GAO Chun-yan, LIU Guo-ling(China-Janan Friendship Institute of Clinical Medical Sciences, Beijing 100029, China);Study on The Effects of Cyclophoshamide on Some Biological Characteristics of Liver Carcinoma Cells in Mice[J];Laboratory Animal Science and Administration;2005-01
Chinese Journal Full-text Database 8 Hits
1 Ren Xiuhua, Zhang Hua, Wu Hongxia, Yan Aihua(Department of Human Anatomy, College of Basic Medical Science, Zhengzhou University, Zhengzhou 450052,China);Expression of TRAIL and Survivin Protein in Carcinogenesis and Development of Esophageal Carcinoma[J];Henan Journal of Oncology;2005-05
2 NIU Hong-qing,LI Xiao-feng~*,ZHANG Li-yun,LIU Ya-ni,RU Jin-li (Department of Rheumatology and Immunology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China);Apoptosis of Peripheral Blood Lymphocytes after Treatment of Rheumatoid Arthritis with Methotrexate and Cyclophosphamide[J];Chinese Journal of Allergy and Clinical Immunology;2008-02
3 WU Kai,MA Mao-qiang,WANG Chun-hai,ZHANG Yong (Department of Patholgy,Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011,Shandong,China);Expression of TRAIL and Survivin proteins in the carcinogenesis and development of laryngeal carcinoma[J];Journal of Otolaryngology and Ophthalmology of Shandong University;2007-02
4 NIU Hong-qing,LI Xiao-feng,ZHANG Li-yun,LIU Ya-ni,RU Jin-li.The Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Influence of cell cycle and apoptosis of peripheral blood lymphocytes after treatment of rheumatoid arthritis with methotrexate and cyclophosphamide.[J];Shanxi Medical Journal;2008-04
5 YANG Liuqin, FANG Dianchun, YANG Shiming, WANG Rongquan, PENG Guiyong, CHEN Wensheng. Institute of Gastroenterology of Chinese PLA, Southwest Hospital, The Third Military Medical University, Chongqing (400038);Construction of Recombinant Adenovirus Containing Soluble Tumor Necrosis Factor-related Apoptosis-inducing Ligand Gene and its Expression in Liver Cancer Cell Line[J];Chinese Journal of Gastroenterology;2008-05
6 YUAN Lin-hong 1,2, ZHANG Ling1, ZHAO Yan1, WU Kun 1 (1Nutrition and Food Hygiene Department, School of Public Health, Harbin Medical University, Harbin 150080; 2Nutrition and Food Hygiene Department, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069);EFFECTS OF VITAMIN E SUCCINATE ON NUCLEAR FACTOR AND ANTI-APOPTOSIS GENES IN HUMAN GASTRIC CARCINOMA CELLS[J];Acta Nutrimenta Sinica;2008-06
7 SUN Hui, ZHANG Jing, ZHAN Zhongli, SUN Baocun, HAO Xishan Department of Pathology, Tianjin Cancer Institute & Hospital, Tianjin 300060, China;The Effect of Estrogen and Estrogen Antagonist on MEK-2 and p-ERK in the MAPK Signal Transduction Pathway in Breast Cancer[J];Chinese Journal of Clinical Oncology;2008-04
8 CHEN Xin-zu, JIANG Kun, HU Jian-kun. Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China;Review of Signal Pathway of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Gastric Carcinoma[J];Chinese Journal of Bases and Clinics in General Surgery;2007-03
Chinese Journal Full-text Database 10 Hits
1 SHI Chang,LIAO Ming yang (Institute of Pharmacology and Toxicology, The Academy of Military Medical Sciences, Beijing 100850, China);EFFECT OF CYCLOPHOSPHAMIDE AND IFOSFAMIDE ON THE FREQUENCIES OF MICRONUCLEUS IN PREGNANCY MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;2000-01
2 \ Zhang Zheng, Zhang Xiuzhen, Li Juesheng, et al\ Department of Biochemistry, Qingdao Medical College, Qingdao 266021;THE EFFECT OF TAURINE ON DNA DAMAGE IN SPLENOCYTES OF MICE[J];;1999-02
3 JIA Qingjun~*,LIU Tianpeng,GUO Kuiliang,et al.~*Bethune military medical college,Shijiazhuang 050081,China;Effect on Testicular Germ Cell after Exposure to Cyclophosphamide in Mice[J];Journal of Bethune Military Medical College;2006-02
4 LI Na,MEI Tong-hua(Department of Respiratory Diseases,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China);Effect of different doses of cyclophosphamide on drug-resistance of implanted human lung cancer in nude mice[J];Acta Academiae Medicinae Militaris Tertiae;2007-16
5 He Tianpei et al.(Dept. of Animal Sci.Univ.of Agri. and Animal Sci., Changchun 130118);Effect of Taurine on Broiler Performance Thyroid Hormones and Immunity[J];JOURNAL OF JILIN AGRICULTURAL UNIVERSITY;1995-02
6 Men Xiuli, Zhang Lianyuan, Zhao Lijun,et al.(Department of Pathophysiology, North China Coal Medical College,Tangshan 063000);The protective effect of taurine on erythrocyte after limb ischemia-reperfusion in rats[J];Journal of North China Coal Medical College;2002-02
7 YANG Jing,MA Li-wen Cancer Center of Peking University the Third Hospital,Beijing 100083,P.R.China;Cancer and the antioxidant defense system[J];Journal of Qilu Oncology;2004-03
8 Qin Chunhua,Shen Jianying,Huang Shine,Wang Guangzu(Institute of Industrial Toxicology,TonjiMedical University,Wuhan 430030,China).;Single Cell Gel Electrophoresis Assay:A DNABreakage Detection Technique.[J];PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS;1995-06
9 LIU Xiang-mei, ZHANG-Yu, MIN Fan-gui, ZHAO Wei-bo, LIU Zhong-hua, ZHANG Li-xin, HUANG-Ren (Guangdong Laboratory Animal Monitoring Institute, Guangzhou 510260, China);Effects of Cyclophosphamide on Leukocyte of C.parapsilosis Infected Mice[J];Laboratory Animal and Comparative Medicine;2007-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiao an, FANG Dian chun, YANG Shi ming,LUO Yuan hui (Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Expression and purification of TRAIL protein and its antitumor activity[J];Acta Academiae Medicine Militaris Tertiae;2001-09
2 Chi Yongchun ,Zhou Shu,Wan Fang et al (Department of Physiology&Pathophysiology, Institute of Clinical Medical Sciences );FLOW CYTOMETRIC ANALYSIS OF THE ANTICANCER EFFECTS OF COPPER ACETATE[J];JOURNAL OF CHINA-JAPAN FRIENDSHIP HOSPITAL;1994-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved