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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Influence of CO_2 pneumoperitoneum on intestinal mucosa barrier in cirrhotic rats

YAN Hong-xian 1,LUO Ding 2,CHEN Xun-ru 2,MAO Jing-xi 2,ZHOU Zheng-dong 2,YU Shao-ming 2(1 Department of Hepatobiliary Surgery,The First People's Hospital in Kunming,Kunming 650011;2Department of Hepatobiliary Surgery,Kunming General Hospital of Chengdu Military Command,Kunming 650032,China)  
Objective To investigate the changes and mechanisms of intestinal mucosa barrier induced by CO 2 pneumoperitoneum in cirrhotic rats.Methods Fifty rats were randomized into four groups:normal control group(Group A),experimental control group(Group B,Veress needle inserted only)and two pneumoperitoneum groups.In pneumoperitoneum groups the abdominal cavity of these rats were insufflated with CO2 and maintained at the pressure of 8 mmHg(Group C)and 13 mmHg(Group D)respectively for 2 h.In condition of sterilization,the portal venous blood was collected and D-lactic acid and endotoxin were measured.The structure of intestinal mucosa was observed.Results All indexes were markedly different(P0.05)between Groups A and B.All values at different time points and pneumoperitoneum pressure were markedly different in Groups C and D in comparison with Group B(P0.05).The endotoxin level(P0.05),the thickness of mucous membrane(P0.05)and the height of intestinal villus(P0.01)were obviously different between Groups C and D.Conclusion Rats with cirrhosis are vulnerable to the damage of intestinal mucosa barrier under the condition of CO2 pneumoperitoneum.
【Fund】: 成都军区科研基金(01A015)~~
【CateGory Index】: R657.3
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