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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Influence of CO_2 pneumoperitoneum on intestinal mucosa barrier in cirrhotic rats

YAN Hong-xian 1,LUO Ding 2,CHEN Xun-ru 2,MAO Jing-xi 2,ZHOU Zheng-dong 2,YU Shao-ming 2(1 Department of Hepatobiliary Surgery,The First People's Hospital in Kunming,Kunming 650011;2Department of Hepatobiliary Surgery,Kunming General Hospital of Chengdu Military Command,Kunming 650032,China)  
Objective To investigate the changes and mechanisms of intestinal mucosa barrier induced by CO 2 pneumoperitoneum in cirrhotic rats.Methods Fifty rats were randomized into four groups:normal control group(Group A),experimental control group(Group B,Veress needle inserted only)and two pneumoperitoneum groups.In pneumoperitoneum groups the abdominal cavity of these rats were insufflated with CO2 and maintained at the pressure of 8 mmHg(Group C)and 13 mmHg(Group D)respectively for 2 h.In condition of sterilization,the portal venous blood was collected and D-lactic acid and endotoxin were measured.The structure of intestinal mucosa was observed.Results All indexes were markedly different(P0.05)between Groups A and B.All values at different time points and pneumoperitoneum pressure were markedly different in Groups C and D in comparison with Group B(P0.05).The endotoxin level(P0.05),the thickness of mucous membrane(P0.05)and the height of intestinal villus(P0.01)were obviously different between Groups C and D.Conclusion Rats with cirrhosis are vulnerable to the damage of intestinal mucosa barrier under the condition of CO2 pneumoperitoneum.
【Fund】: 成都军区科研基金(01A015)~~
【CateGory Index】: R657.3
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【References】
Chinese Journal Full-text Database 1 Hits
1 JIA Li-feng,ZHANG Lian-yang,LI Yong(State Key Laboratory of Trauma,Burns and Combined Injury,Department of Trauma and Injuries,Institute of Surgical Research,Daping Hospital,Third Medical Military University,Chongqing 400042,China);Effects of CO_2 pneumoperitoneum on hepatic function and hepatic blood flow after hemorrhagic shock resuscitation in rabbits[J];Acta Academiae Medicinae Militaris Tertiae;2009-11
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Shi,LIANG Zhi-qing,YAN Jun-ling(Department of Obstetrics and Gynecology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Effect of CO_2 pneumoperitoneum on expressions of β_1-integrin and E-cadherins in endometrial cancer cells transplanted into nude mouse[J];Acta Academiae Medicinae Militaris Tertiae;2008-13
2 WEN Yi, GAO Xue-mei, WANG He, CHENG Wei. Department of Obstetric and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China;Effect of 100% CO_2 or 5% Dextrose as Distending Uterine Cavity Medium on the Proliferation and Apoptosis of Endometrial Carcinoma Cell in vitro[J];Journal of Sichuan University(Medical Science Edition);2007-03
3 ZHANG Jun-ming,ZHANG Chan,REN Yan-hua,LIU Fen,LEI Ya-ning.Department of Histology and Embryology,Wenzhou Medical College,Wenzhou,Zhejiang 325035,China;Effects of CO_2 pneumoperitoneum on enteric motor function and enteric nervous system in rat[J];Medical Journal of Chinese People's Liberation Army;2009-02
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