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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Degradation of chitosan film under rabbit scleral flap and its effect on intraocular pressure

SHANG Xu-min 1,JIN Zhong-qiu 1,ZHOU He-zheng 1,ZHOU Xiong 1,ZHANG Wen-qiang 1,CHEN Hua-xin 1,WANG Bai-chuan 1,GAO Yu-xiang 2(1Department of Ophthalmology,Wuhan General Hospital of Guangzhou Military Command, 2Biomedical Materials and Engineer Center,Wuhan University of Technology,Wuhan 430070,China)  
Objective To observe the degradation of chitosan film under rabbit scleral flap,eye irritation,and intraocular pressure and estimate biocompatibility of chitosan film and the effect of lessening intraocular pressure.Methods Chitosan film was extracted from shell of snow-crab.Sixteen rabbits(32 eyes)were divided randomly into 2 groups with 16 eyes in each group.Group A was treated with trabeculectomy as control and Group B treated with trabeculectomy and implantation of chitosan film under scleral flap.The intraocular pressure,inflammatory reaction,pathological change after operation were observed.Results There were no significant alterations regarding the cornea and iris.Inflammatory reaction was seen on day 7 after operation.Partial chitosan film degradation appeared and inflammatory reaction remitted on day 14 after operation.The chitosan film was degraded into fragment and the inflammatory reaction almost disappeared on day 56 after operation.There existed tissue space and follicles around the implanted materials in Group B;in Group A,however,instead of tissue space and follicles,histological structure disarrangement and cicatrisation were noticed.The intraocular tension varied significantly between the two groups at 8th week postoperatively(P0.01).Conclusion Chitosan film has good histocompatibility and inhibitory effect on fibroplasia.It can effectively decline intraocular pressure.
【CateGory Index】: R779.6
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Chinese Journal Full-text Database 5 Hits
1 LIU Shao zhang, YU Chun zhi, HE Xiang ge (Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing 400042);Pathological changes of the trabeculae in 628 cases of primary angle closure glaucoma and their clinical significance[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;2000-02
2 ;Early therapeutic effect of aqueous humor drainage device implantation for refractory glaucoma[J];Acta Academiae Medicinae Militaris Tertiae;2005-03
3 WANG Tao, AI Guo-ping, DU Zhi-yong, TAN Hu, SU Yong-ping (State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Treatment for mice with minor gastrointestinal type combined radiation and burn injury[J];Acta Academiae Medicinae Militaris Tertiae;2005-21
4 Zhang-Qiu Jin, Qing-Hua Zhang, Yan-Ping Song. Department of Ophthalmology, Wuhan General Hospital of Guangzhou Military Command Area, Wuhan 430070, Hubei Province, China;Effect of suprachoroidal space drug administration in perforating ocular injury in rabbits[J];International Journal of Ophthalmology;2003-02
5 CHENG Jin-xue,HU Ping,LI Xiao-ling,GAO Feng,HUANG Yi-fei(Department of opthalmology, PLA Genertal Hospital,Beijing 100853,China);Chitosan membrane on nonpenetrating filtering in rabbits[J];Academic Journal of Pla Postgraduate Medical School;2002-02
Chinese Journal Full-text Database 10 Hits
1 ;Changes of visual electrophysiology and contrast sensitivity in patients with early primary angle-closure glaucoma[J];Journal of Jilin University of (Medicine Edition);2004-03
2 ZHONG Ling (Department of Ophthalmology,the 1st People′s Hospital of Yibin,Yibin,Sichuan 644000,China);Trabeculectomy combined with mitomycin C and controlled suture in primary glaucoma[J];Chongqing Medicine;2006-06
3 Li Huilin,Liu Wei,Ji Jian Tian Jin medical university eye centre;The Application of two-site Phacotrabeculectomy with Adjustable Suture in Cataract and Glaucoma Patients[J];Journal of Changzhi Medical College;2008-02
4 LI Gui-xiang LI Han-Zhao,YANG Chao-ju et al(Department of Ophthalmology,Indirect Affiliated Hospital of Dali College,Yunnan Dasli 671000 China);Clinical Observation of Complex trabcula Resection[J];Journal of Dali College;2003-03
5 QIU Rui-ying,ZHANG Shu-fen (Department of Ophthalmology,Shanghai Li Qun Hospital,Shanghai 200060,China);Cataract extraction and phacoemulsification with intraocular lens inplantation in patients after glaucoma surgery[J];Journal of Dalian Medical University;2001-01
6 SU Jing, LUO Zhao-wen (Department of Ophthalmology,the Fourth Affiliated Hospital of Dalian Medical University,Dalian 116001, China);Cause and manage of shallow anterior chamber after trabeculectomy of glaucoma[J];Journal of Dalian Medical University;2003-03
7 GUO Xiao-shu1,2, FANG Hai-li2, LI Jun1, SU Yong-ping1 (1State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University; Chongqing 400038; 2Department of Physiology, School of Preclinical Medicine, Chongqing Medical University,Chongqing 400016,China);Effect of cervical sympathetic block on hepatic interferon-induced protein IFIT1 in burned mice during early stage[J];Acta Academiae Medicinae Militaris Tertiae;2007-17
8 MA Jian-zhou, HE Xiang-ge, XIE Lin, SUN Ya-li (Department of Ophthalmology, Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Variations of flash visual evoked potential in SD rats with intraocular hypertension[J];Acta Academiae Medicinae Militaris Tertiae;2007-22
9 GONG Ji-Ping1,2,CHEN Yu-Pei2,GUO Xiao-Shu3,SU Yong-Ping11PLA Institute of Combined Injury,& State Key Laboratory of Trauma,Burns and Combined Injury,Third Military Medical University,Chongqing 400038 China,2Department of Anesthesia,School of Second Clinical Medicine,Chongqing Medical University,Chongqing 400010,China,3Department of Physiology,School of Preclinical Medicine,Chongqing Medical University,Chongqing 400016,China;Effect of cervical sympathetic block on Interferon-induced protein IFIT1 levels in organs of burned mice during early stage[J];Journal of the Fourth Military Medical University;2009-06
10 Song XiFan FuJian\ Mega\ Ophthalmic\ Center,Fujian 350003,China Xiong xing Ophthalmology department Yong An hospital,Fujian 366000,China;Treatment of angle-closure glancoma by phacoemulsification with intraocular lens implantation[J];Fujian Meidical Journal;2002-04
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHU Jun dong, SU Yong ping , CHENG Tian min (Institute of Combined Injury, Third Military Medical University, Chongqing 400038,China);Effects of glucagon-like peptide 2 on recovery of small intestinal epithelia from radiation injury in mice[J];Acta Academiae Medicine Militaris Tertiae;2001-03
2 LU Jian-hua, SU Yong-ping, CHENG Tian-min, DU Zhi-yong (State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Roles of cervical sympathetic ganglia block in the treatment of mice with combined radiation and burn injury[J];Acta Academiae Medicinae Militaris Tertiae;2005-12
3 WU Qiang (Orthopaedic department,Union Hospital,Wu Han 430022,China);The application of chitosan in cartilage tissue engineering[J];Foreign Medical Sciences Biomedical Engineering;2002-02
4 Xing Jianqiang;Han Zhonglin;Chen Xiaoyan (Department of Ophthalmology,Affiliated Hospital of Hainan Medical College,Halkou,Hainan 570005);Intraocular Injection of Triamcinolone Acetonide applied to the Treatment of Uveitis[J];NATRUAL SCIENCE JOURNAL OF HAINAN UNIVERSITY;1994-02
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