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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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On tolerance limit for normothermic hepatic inflow occlusion by meso-caval shunt in Bama swines

CHEN Ji-ye,MA Zheng-wei,DONG Jia-hong(Institute of Hepatobiliary Surgery,Southwest Hospital,Third Military Medical University,Chongqing 400038,China)  
Objective To establish an animal model of hepatic inflow occlusion with meso-caval shunt in Bama swines so as to evaluate the tolerance limit of normothermic hepatic inflow occlusion.Methods Eighteen Bama swines were divided into group A in which the hepatic blood inflow was occluded for 90 min and group B in which the hepatic blood inflow was blocked for 100 min.The animal survival rate,the changes of liver function and histopathology were observed.Results The animal survival rate was significantly higher in group A than group B(100% vs 44.4%,P0.05).Compared with the pre-ischemia value,ALT levels in the two groups on the 2 nd and 3 rd day postoperatively were significantly increased.On the 4 th day postoperatively ALT recovered to normal level.ALT level was significantly higher in group B than group A on the 2 nd and 3 rd days postoperatively.AST in the two groups peaked at 1 h after reperfusion,and recovered to normal on the 3 rd day postoperatively.AST was significantly higher in group B than group A at 1 h after reperfusion and on the 1 st and 2 nd days postoperatively.T-BIL and D-BIL levels in group A at ischemia 90 min were significantly higher than the pre-ischemia levels,and then decreased to the normal level.T-BIL,D-BIL levels in group B peaked after 100 min of ischemia,and returned to normal on the 5 th day postoperatively.T-BIL and D-BIL levels in group B were significantly higher than group A at the end of ischemia,1 h after reperfusion and postoperative days 1-4.Hepatic injury was severer at 1 h after reperfusion in both groups.The hepatic tissue recovered to normal in group A on the 4 th day postoperatively;however,hepatic necrosis was found in group B.Conclusion Ninety minutes is the tolerance limit for normothermic hepatic inflow occlusion in swine under conditions of meso-caval shunt.
【Fund】: 国家杰出青年科学基金海外青年合作研究基金(30228030);; 国家自然科学基金青年基金(30400436)~~
【CateGory Index】: R657.3
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