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《Acta Academiae Medicinae Militaris Tertiae》 2007-04
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Change and significance of myelin proteolipid protein expression in aged rats

CHENG Rong-chuan 1,ZHAO Shi-fu 1,WANG Ya-li 2,LIU Yong 1,ZHOU Zhu-juan 1(1 Department of Neurology, 2 Department of Pathology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China)  
Objective To investigate change of myelin proteolipid protein(PLP)expression,myelin structures,central conductive function and the relationship among them in aged rats.Methods Eighteen rats aging 18-24 months and 18 at 6-7 months were subjected.Immunohistochemistry was applied to detect the expressive changes of PLP.LEICA QWIN image analytical system was used to show integrated optical density(IOD)of PLP immunostaining.Transmission electron microscopy(TEM)was used to observe the ultrastructural changes of white matter in rats,such as myelin sheath and axon.The conductive latency of perforant pathway was recorded by electrophysiological methods to evaluate central conductive function of forebrain regions in rats.Results Immunohistochemistry showed PLP was positive expressed in the striatum,callosum,anterior commissure,subcortex regions in 2 groups.But the PLP expression was significantly decreased in aged group than in young group(P0.01).There were obvious differences in the ultrastructure of white matter.Aged rats had enlarged axons with megamitochondria in them and increased gaps among axon and myelin,separated compact layer,even confused,destructed in myelin sheath.The central conductive latency was increased significantly in aged group than young group(P0.01).Conclusion Aged rats have decreased PLP expression,which might be relevant to the morphological and structural changes of myelin sheath,and have certain relation with the decline of conductive function during brain aging.
【Fund】: 国家自然科学基金(30170311)~~
【CateGory Index】: R341
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