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《Acta Academiae Medicinae Militaris Tertiae》 2007-12
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On anticancer activity of isoflavone derivative F11

ZHANG Li-long1,AI Guo-ping1,SU Yong-ping1,CHENG Tian-min1,ZHENG Hu2,WENG Ling-ling2(1State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Combined Injury,College of Preventive Medicine,Third Military Medical University,Chongqing 400038;2West China School of Pharmacy,Sichuan University,Chengdu 610041,China)  
Objective To investigate whether structurally modified isoflavone derivatives have better antitumor activity in vivo and in vitro.Methods The antiproliferative activity of compound F11 against Hela strain cells was analyzed by MTT and compared with that of Genistein.The nude mouse loading Hela tumor cells was used to evaluate the in vivo antitumor activity of F11 and the results were compared with that of Genistein and Cytoxan.Results Compound F11 had better performance than Genistein in antitumor tests as revealed by in vitro MTT measurement and in vivo nude mice model loading Hela tumor cells.Conclusion Isoflavone derivatives could be modified to acquire potent cytotoxicity on tumor cells,which are of potential clinical value and worth further investigation.
【Fund】： 重庆市院士基金(2004BC5006)~~
【CateGory Index】： R73-36
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