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《Acta Academiae Medicinae Militaris Tertiae》 2007-12
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Mutation of E6 genes of human papillomavirus type 52 in cervical cancer patients in Guangdong province

ZENG Li1,GUO Sui-qun2,YUN Jing-ping3,XIE Bo4,YU Shou-yi1(1Department of Epidemiology,School of Public Health and Tropical Medicine,2Department of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,3Department of Pathology,Cancer Hospital of Sun Yat-sen University,Guangzhou 510060,4Department of Obstetrics and Gynecology,The Second Chinese Medicine Hospital of Guangdong Province,Guangzhou 510095,China)  
Objective To study the infectious rates and features of E6 genes of HPV52 in cervical cancer patients in Guangdong province and provide epidemic data for development of HPV vaccine suitable for Chinese population.Methods DNA samples of 130 cervical cancer tissues from patients in Guangdong province were amplified by HPV-specific PCR with consensus primers,then the E6 genes of HPV52 were sequenced for mutation analysis.Results Eight HPV52-positive cases were found in 130 cases and the infectious rate of HPV52 was 6.15%.E6 region nucleotide variation in 3 of the 8 cases were characterized by PCR-directed sequencing.Conclusion Compared with the HPV52 prototypes published in GenBank,several new point mutations at the E6 genes of HPV52 were found in only one case out of the three cases subjected to PCR-directed sequencing and these mutations are closed to those found in Hong Kong.
【CateGory Index】: R737.33
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【References】
Chinese Journal Full-text Database 1 Hits
1 YU Nan,GU Wei-wei,LIU Hong-e,SUN Hong-qing,ZHAN Xi-mei,CHEN Xiao-jian(Guanzhou Economic and Technological District Hospital,Guangzhou 510730,China);Distribution of the genotypes of human papillomavirus in east Guangzhou and coding sequences of E6/E7 of the dominant genotype[J];Chinese Journal of Zoonoses;2009-03
【Citations】
Chinese Journal Full-text Database 3 Hits
1 WU Yu-ping~(1*), CHEN Yu-long~1, LI Long-yu~2, LIANG Zeng-wen~1, ZHANG Yan-ling~2(1. School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;2. Maternal and Child Health Hospital of Jiangxi Province, Nanchang 330046, China);Major Genotypes of Human Papillomavirus and Its Infection Prevalence in Women with Cervical Cancer[J];Chinese Journal of Virology;2005-04
2 REN Yuan,WU En-qi, ZHANG Guo-nan,et al (Sichuan Cancer Hospital, Chengdu 610041, China;Vaccine Center of Jilin University, Changchun 130023,China);Analysis of Mutations of E6 Genes of Human Papillomavirus(HPV) Type 33,52 and 58 in the Patients with Cervical Cancer in Sichuan Area[J];Sichuan Journal of Cancer Control;2006-01
3 LIU Ji-hong *,HUANG Xin,LIAO Ge-wang,LI Jun-dong,LI Yah-fang,LI Meng-da,Barbara ROSE,Carol THOMPSON. *Department of Gynecologic Oncology,Cancer Center,Sun Yat-sen University;Guangzhou 510060,China$Depatrment of Infections Diseases,the University of Sydney;Human papillomavirus infection and other risk factors for cervical cancer in Chinese and Australian patients[J];National Medical Journal of China;2003-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Can-Yu,LIU Ji-Hong,HUANG Bi-Jun 1.Department of Gynecologic Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 2.Research Department,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China;Correlation between P53 Codon 72 Polymorphism and Tumorigenesis of Cervical Cancer[J];Chinese Journal of Cancer;2004-S1
2 LI Quan1,ZHU Hong-yong1,YANG Qing-ping1,et al.(Department of Clinical Laboratory,Changshou People′s hospital,Chongqing 401220,China);Application of real-time polymerase chain reaction and hybrid capture Ⅱ in high-risk human papillomavirus detection[J];Chongqing Medicine;2008-24
3 JIA Ying,ZHOU Min,WU Jin,TANG Liang-dan (Department of Obstetrics and Gynecology,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China);Clinical value of human papillomavirus genotype distribution in HPV infection[J];Acta Academiae Medicinae Militaris Tertiae;2009-23
4 ZENG Li1, YU Shou-yi1, HU Zhao-hui2, ZHANG Jun3 1Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China; 2Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou 510182, China; 3Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;Polymorphisms of human papillomavirus type 81 L1 gene in patients with cervical lesions in Guangdong[J];Journal of Southern Medical University;2008-12
5 ZENG Li1, YU Shou-yi1, GOU Sui-qun2, YUN Jin-ping3, ZHANG Jun4 1Department of Epidemiology, School of Public Health and Tropical Medicine, 2Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 3Department of Pathology, Cancer Hospital of Sun Yat-sen University, Guangzhou 510060, China; 4Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;Identification and genotyping of oncogenic type of human papillomavirus in paraffin-embedded cervical cancer samples in Guangzhou[J];Journal of Southern Medical University;2009-12
6 YANG Yingjie, ZHAO Jian, LI Xueqian, et al. (Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.);The association between human papillomavirus (HPV) types infection and the cervical lesions[J];Chinese Journal of Clinical Obstetrics and Gynecology;2006-04
7 Wan Xiaotao,Zhong Fangcai(Department of Laboratory,the First People's Hospital of Neijiang City,Neijiang Sichuan 641000,China);HPV subtype analysis in 474 cases of suspected patients with cervical diseases[J];International Journal of Laboratory Medicine;2012-07
8 CEN Yao~(1#) ZHANG Cui-ying~2 ZHANG Ya-li~3 HOU Jian-hua~1 1 Department of Obstetrics and Gynecology,2 Department of Medical Oncology,Inner Mongolia Hospilal,Huhhot,010017,China 3 Inner Mongolia international Mongolian hospital,Huhhot,010020,China;Meta-analysis of human papillomavirus(HPV) infection and high-risk type distribution in Chinese women[J];Oncology Progress;2013-01
9 Cao Qingxiang;Gao Hong;Tang Qing;Dai Wen;Xie Wenliu;Wan Yanping;Department of Clinical Laboratory,Hengyang Municipal Maternal and Child Health Care Hospital;Institute of Nursing,School of Nursing,University of South China;;Analysis on infection status quo of 21 kinds of genotypes of human papillomavirus among women in Hengyang region[J];International Journal of Laboratory Medicine;2014-14
10 SU Xi-kang, CUI Jin-huan, YANG Guang(Laboratory Department, the First People's Hospital of Foshan City, Guangdong 528000, China);Study on Human Papillomavirus Genotyping in Cervical Cancer[J];Journal of Clinical Research;2008-06
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 ZHAO Na1,ZHAO Fang-hui2※,GAO Xiao-hong1※,WEI Li-hui3,XU Ai-di4,LI Chang-qin5,MA Jun-fei6,QIAO You-lin2 1.Department of Epidemiology,Dalian Medical University,Dalian 116044,P.R.China 2.Department of Epidemiology,Cancer Institute and Hospital,Chinese Academy of Medical Sciences,Beijing 100021,P.R.China 3.Department of Gynaecology and Obstetrics,People's Hospital of Peking University,Beijing 100044,P.R.China 4.Hongkou District Board of Health,Shanghai 200437,P.R.China 5.Xinmi City Women and Children's Hospital,Xinmi 450012,P.R.China 6.Xiangyuan County Women and Children's Hospital,Xiangyuan 046200,P.R.China;Risk factors of high-risk human papillomavirus infection in urban and rural area of China[J];Chinese Journal of Cancer Prevention and Treatment;2011-16
2 REN Yuan,WU En-qi, ZHANG Guo-nan,et al (Sichuan Cancer Hospital, Chengdu 610041, China;Vaccine Center of Jilin University, Changchun 130023,China);Analysis of Mutations of E6 Genes of Human Papillomavirus(HPV) Type 33,52 and 58 in the Patients with Cervical Cancer in Sichuan Area[J];Sichuan Journal of Cancer Control;2006-01
3 BAO Yan-ping~* LI Ni WANG He QIAO You-lin Department of Cancer Epidemiology,Cancer Institute Hospital,Chinese Academy of Medical Science,Beijing 100021,China;Study on the distribution of human papillomavirus types in cervix among Chinese women:a Meta-analysis[J];Chinese Journal of Epidemiology;2007-10
4 ZHANG Xin WANG Chun-yan SHI Ju-fang GAO Yan LI Lian-kun Department of Gynecology Oncology,Liaoning Tumor Hospital,Shenyang 110042,China;Study on the prevalence of human papiliomavirus infection and distribution of types in Shenyang city[J];Chinese Journal of Epidemiology;2007-10
5 ZHAO Jian, YANG Ying-jie, LIAO Qin-ping. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China;Application of flow-through hybrization and gene chip on human papillomavious subtype detection in clinical[J];Chinese Journal of Laboratory Medicine;2006-12
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 GAO Peng,ZHANG Yong-mei,XIA Yu(Department of Clinical Laboratory,Second People's Hospital of Xiangtan City,Xiangtan 411100,China);Distribution and Characteristics of Human Papillomavirus Genotypes in Female Lower Genital Tract Infection in Xiangtan Region[J];Labeled Immunoassays and Clinical Medicine;2011-01
2 Gao Peng;Zhang Yongmei;Xia Yu;Department of Clinical Laboratory,Second Peopleg Hospital of Xiangtan City;;Distribution and Characteristics of Human Papiilomavirus Genotypes in Female Lower Genital Tract Infection in Xiangtan Region[J];Journal of Changsha Medical University;2014-01
3 ZHANG Xing-ping;XIAO Ke-lin;Department of Dermatology,Shenzhen Bao'an Maternal and Child Health Hospital;Department of Clinical Laboratory,Shenzhen Bao'an Maternal and Child Health Hospital;;Infection Status and Gene Subtypes of Human Papilomavirus in Cervix[J];Journal of Diagnosis and Therapy on Dermato-venereology;2014-01
4 Sajida.Saimaiti,Mireguli.Kasimu,LIU Xin-hua,et al.(Xinjiang Uygur Autonomous Region People's Hospital,Urumqi 830002,P.R.China);Detection and genotyping of human papilloma virus in female genital tract in Urumqi[J];China Tropical Medicine;2011-09
5 NI Bing ZHU Shunhui SHI Wenjuan ZHAO Yun GU Qingjie MA Jiyun ZHANG Ming DUAN Neng The Biological Immune Research Laboratory of the Third People's Hospital in Gejiu City of Honghe Prefecture,Yunnan Province,Gejiu 661000,China;Research of women's cervix HPV infection and genotypes in Gejiu city of Yunnan[J];China Modern Doctor;2012-12
6 WU Shao-qing,LIAO Can,HUANG Yi-ning,LI Yan,SHA Wen-qiong,LI Fa-tao,LI Dong-zhi. Institute of Birth Health Perinatology,Guangzhou Women and Children's Medical Center,Guangzhou 510623,China;Analysis of detection of human papillomavirus in 6493 cases in Guangzhou[J];Chinese Journal of Practical Gynecology and Obstetrics;2011-06
7 CHEN Zhi-Xin,CHEN Jian-Sen(Fujian Medical University Affiliated Union Hospital,Fuzhou 350001,China);Prevalence of human papillomavirus genotype in cervical lesion[J];Chinese Journal of Zoonoses;2013-01
8 YIN De-ying;LIU Xia;TIAN Bing;Department of Clinical Laboratory,Lanzhou Municipal Hospital of Maternal and Child Care;;Genetic screening of papilloma virus genes in female patients[J];Chinese Journal of Healthy Birth & Child Care;2013-05
9 LIU Feng;LI Zheng;CHENG Si;Department of Laboratory Medicine,General Hospital of Yunnan Armed Police Force;Department of Laboratory Medicine,Kunming Yan'an Hospital;;Epidemiological investigation on human papilloma virus infection in Yunnan province[J];Journal of Chongqing Medical University;2013-09
10 HOU Jun-Ran;YE Song-Shan;YUAN Min;Medical Experiment Center of of Nanyang Institute of Technology;;Analysis of the distribution of high-risk HPV genotypes and age characteristics of female cervical cancer in Southwest Henan[J];Maternal and Child Health Care of China;2014-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Ji-hong *,HUANG Xin,LIAO Ge-wang,LI Jun-dong,LI Yah-fang,LI Meng-da,Barbara ROSE,Carol THOMPSON. *Department of Gynecologic Oncology,Cancer Center,Sun Yat-sen University;Guangzhou 510060,China$Depatrment of Infections Diseases,the University of Sydney;Human papillomavirus infection and other risk factors for cervical cancer in Chinese and Australian patients[J];National Medical Journal of China;2003-09
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