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《Acta Academiae Medicinae Militaris Tertiae》 2007-12
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The quantitative equation of mannitol for high intracranial pressure in intracerebral hemorrhage patients

TAN Ge,ZHOU Ji-ying,LIU Bo-wen,MAO Yuan-chao,LIAO Qi(Department of Neurology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)  
Objective To study the relationship of decreasing intracranial pressure with mannitol dose and other factors so as to deduce the individual dosage.Methods The intracranial pressure of 72 patients was monitored daily by NIP-200 noninvasive intracranial pressure apparatus.The effect of decreasing intracranial pressure,the corresponding mannitol dose,gender,age,bleeding part and volume of hematoma were recorded.These data were applied for multivariate regression analysis,then the influencing factors were applied for analysis of multiple covariance.Results The reduction of intracranial pressure was found no statistic significance with gender,age(P0.05),but statistically related to bleeding part,volume of hematoma and mannitol dose(P0.05).The reduction of intracranial pressure of supratentorial intracerebral hemorrhage by mannitol was better than that of subtentorial intracerebral hemorrhage.Conclusion We can calculate the individual mannitol doses according to patients' bleeding part,volume of hematoma and the highest intracranial pressure when hospitalized.
【Fund】: 重庆市卫生局重点项目(1999-1001);; 重庆市卫生局医学科研项目(2000-2028)~~
【CateGory Index】: R743.34
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