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《Acta Academiae Medicinae Militaris Tertiae》 2008-01
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Effects of hypoxia on viscoelastic properties of polymorphonuclear leukocyte of rats

ZHANG Gang, GAO Yu-qi, LIU Fu-yu (1Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical university, Chongqing 400038, China)  
Objective To explore the effects of acute or chronic hypoxia on the viscoelastic properties of polymorphonuclear leukocyte (PMN) of rats. Methods Hypobaric chamber was used to simulate high altitude condition. Fifteen adult Wistar rats were randomized into 3 groups: control, acute hypoxia (5 000 m for 3 d) and chronic hypoxia (5 000 m for 30 d). Micropipette aspiration technique was used to evaluate the biomechanical properties of PMNs of rats and the experimental results were fitted with a three-element standard linear solid model. Results The viscoelastic coefficients of PMNs in acute hypoxic condition [K1=(86.66±26.84) Pa, K2=(399.89±22.03)Pa, μ=(4.23±1.82) Pa·s] or those values in chronic hypoxic condition [K1=(179.61±26.31) Pa, K2=(472.12±30.36) Pa, μ=(9.21±2.65) Pa·s] were significantly higher than the corresponding value of PMNs in control(P0.05) [K1=(39.52±16.06) Pa,K2=(148.85±9.06) Pa,μ=(2.28±1.11) Pa·s]. Compared with the control, the initial strain, maximum strain and the time constant in acute hypoxia was obviously decreased(P0.05), but the time constant in chronic hypoxia had no difference. Conclusion These results suggest that acute or chronic hypoxia has strong impact on the biomechanical properties of PMN, involving the increased rigidity of cell membrane and the decreased deformation of cell.
【CateGory Index】: R392
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Gang,GAO Yu-qi,ZHANG Lu(1.Department of Pathophysiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China;2.Chongqing Jianshe Hospital,Chongqing 400050,China);Effects of hypoxia on hemorheologic properties of rats[J];Chongqing Medicine;2006-17
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 XIAO Juan,XIAO Ying-bin△,CHEN Lin,et al.(Department of Cardiovascular Surgery,Xinqiao Hospital,The Third Military Medical University,Chongqing 400037,China);Mitochondrial biogenesis in hearts of congenital heart disease with cyanosis[J];Chongqing Medicine;2008-09
2 LI Lu1,LIU Xiangyu2,LI Deshan2(1.Life Science and Biotechnique Research Center,Northeast Agricultural University,Harbin 150030,China;2.College of Life Sciences,Northeast Agricultural University,Harbin 150030,China);Sorting neutrophil from leucocyte by flow cytometer[J];Journal of Northeast Agricultural University;2009-04
3 Zhang Gang, Gao Yuqi, Liu Fuyu. Department of Pathophysiology, College of Plateau Military Medicine, Third Military Medical University, Chongqing 400038, China;Rheological changes of leukocyte and expression of integrin CD18 in rats under hypoxia[J];Medical Journal of Chinese People's Liberation Army;2008-01
4 LIN Lin1,TAO Chun1,JIANG Hui2,BAO Lan3,SONG Bao-hua1,TANG Wen-li1,BAO Gui-lan1,BA Yan-yan1,LIU Yu-mei1,LU Pin1,LIU Yue-ying1(1.The Inner Mongolia University for The Nationalities,Tongliao 028000 China;2.The Inner Mongolia Xing'an League Hospital,Wulanhaote 137400 China;3.The Hospital of Hulunbeier City,Hailaer 021000 China);The Erythrocyte Deformability and Influence on Microcirculation[J];Inner Mongolia Medical Journal;2008-12
5 YAN Yu-wen,LI Peng,XING Jie,MA Ping,Wang Zeng-tian(Department of Parasitology,Medical College of Chinese People′s Armed Police Force,Tianjin 300162,China);Effects of IgG and IgE in immune mechanism of trichinosis on the muscular larvae of Trichinella spiralis[J];Acta Academiae Medicinae CPAPF;2007-04
6 XIAO Juan,XIAO Ying-bin,CHEN Lin,et al (Department of Cardiovascular Surgery,Xinqiao Hospital,The Third Military Medical University,Chongqing,400037);Changes of mitochondrial DNA copy in congenital heart disease with cyanosis[J];Medical Journal of West China;2008-04
7 Zhu Rong1,Gao Qi1,Tian Ye2,Hu Yang1,Zhao Jiexiu21 Beijing Sport University,Beijing,China 1000842 Chinese Institute of Sport Science,Beijing,China 100061;Effects of HiHiLo on Erythrocyte Membrane and Aerobic Exercise Capacity in Elite Female Kickboxing Athletes[J];Chinese Journal of Sports Medicine;2008-01
8 ZHANG Gang,GAO Yu-qi(Department of Pathophysiology,College of High Altitude Military Medicine,Third Military Medical University,Chongqing 400038,China.);Effect of hypoxia on chemotaxis of rat polymorphonuclear leukocytes[J];Chinese Journal of Pathophysiology;2008-03
9 LI Peng,XING Jie,YAN Yu-wen,MA Ping(Department of Parasitology,Medical College of Chinese Armed Police Forces,Tianjin 300162,China);The neutrophil and monocyte-mediated ADCC effects in immune mechanism of trichinosis[J];Journal of Pathogen Biology;2007-03
China Proceedings of conference Full-text Database 1 Hits
1 Zhu Rong Gao Qi (Beijing Sport University,Beijing,China 100084);Effect of HiHiLo on Erythrocyte membrance stability and aerobic Exercise Capacity in Chinese Kickboxing Athletes[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 GUO Xiao li, GE Heng jiang (Department of Anesthesiology, Daping Hosiptal, the Third Military Medical University, Chongqing 400042);Hemorheology property effects of hypervolemic hemodilution using artificial colloid solution or cyrstalloid solution[J];Chongqing Medical Journal;2002-04
2 Liang Wanyi, Luo Decheng, Zhang Guobin, Gao Yuqi (Department of Pathophysiology, Third Military Medical University, Chongqing, 400038);Deformative changes of erythrocytes and its mechanism during hypobaric hypoxia in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-01
3 Wu Zezhi; Li Zhiqing; Long Mian; Luo XiangdongSong Guanbin; Wang Hongbin; Wu Yunpeng(Biorngineering Center, Chongqing Univeristy, Chongqing 630044 ) (Burn Institute. 3rd Millitary medical College, Chongqing 630038);Investigation on the Mechanical Properties of Adhesion between Granulocytes and Endothelial Cells in Burnt Rats[J];Journal of Biomedical Engineering;1996-03
4 Liang Wanyi Luo Decheng Gao Yuqi Zhang Guobin(Department of Pathophysiology, Third Military medical University, Chongqing 400038);STUDIES OF MECHANISM OF ERYTHROCYTE DEFORMABILITY INJURY DURING HYPOBARIC HYPOXIA IN RATS[J];CHINESE JOURNAL OF APPLIED PHYSIOLOGY;1997-04
5 ZHAO Jing, Joern Heine, Siegfred Piepenbrock, et al. Department of Anesthesia, Peking Union Medical College Hospital, Beijing 100730, China;The effect of propofol on respiratory burst of polymorphonuclear leukocytes of different preparation[J];Chinese Journal of Anesthesiology;2002-08
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