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《Acta Academiae Medicinae Militaris Tertiae》 2008-05
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Prostaglandin E_2 in peripheral blood and tumor mass of patients with gastric cancer

YU Hui-hong, WU Xiao-ling, ZHANG Mu, NING Bo (Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China)  
Objective To assess the prostaglandin E2 (PGE2) levels in tumor mass and peripheral blood of patients with gastric cancer and explore their clinical significance. Methods The PGE2 levels in tumor mass, tumor margins of excision and peripheral blood of 40 patients with gastric cancer were measured by a kit of PGE2 ELISA. Results The PGE2 levels were higher in the tissues of gastric cancer than in tumor margins of excision [(8.225±2.425) vs (1.669±0.287) ng/g, P0.01]. The PGE2 levels in tissues of low and mid-high differentiation cancer were (9.02±2.28) and (5.38±0.35) ng/g respectively, with statistically significance (P0.05). The PGE2 levels in peripheral blood was positively correlated to that in tissue of gastric cancer (r=0.889,P0.01). Peripheral blood PGE2 level was statistically higher in the tumor more than 5 cm in size than in that less than 5 cm (P0.05), which were (121.15±38.31) and (78.48±23.76) pg/ml respectively. Statistically significance was observed in the PGE2 levels in peripheral blood between low and mid-high differentiation gastric cancers [(115.5±39.17) vs (73.28±17.68) pg/ml, P0.05]. There was no significant correlation between different ages, different sexes, site of tumor, depth of invasion, clinopathological type or lymph node involvement. Conclusion The PGE2 levels in tumor mass and peripheral blood of patients with gastric cancer are elevated, indicating a positive correlation of the levels in two samples. Peripheral blood PGE2 level might be used to evaluate the size and differentiation of tumor. gastric cancer.
【CateGory Index】: R735.2
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