Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Militaris Tertiae》 2008-10
Add to Favorite Get Latest Update

Alternation of blood pressure and behavioral performance in rat offspring following maternal inflammation during pregnancy

HAO Li-yun,LI Xiao-hui(Department of Pharmaceutics,College of Pharmacy,Third Military Medical University,Chongqing 400038,China)  
Objective To explore the effect of prenatal inflammation on rat offspring's blood pressure and behavioral performance.Methods Twenty-four time-mated Sprague-Dawley(SD)rats were randomly divided into three groups,i.e.control,zymosan and LPS.On their gestation days 8,10,12,the pregnant rats received i.p.injections of sterile saline,0.79 mg/kg zymosan or 0.79 mg/kg LPS respectively.When the offspring were sixty weeks old,eight pups were chosen randomly for the later study.Their serum TNF-α level was detected by ELISA using tail blood,arterial blood pressure was measured by tail-cuff method,and their behavioral performance was detected in Morris water maze test.At the end of the experiment,the brains were rapidly taken from the sacrificed offspring,cut into sections and stained with HE method to investigate the structural changes of hippocampus.Results Compared with control group,all offspring from the inflammation groups showed increased serum level of TNF-α,increased systemic arterial blood pressure,long latency in finding the safe platform and decreased number of neurons in CA1 region of hippocampus.Conclusion Prenatal exposure to LPS or zymosan results in hypertension and disturbance of learning and memory.
【Fund】: 国家自然科学基金(30672641)~~
【CateGory Index】: R714.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 MIAO Ying,TANG Yuan,LI Xiao-hui(Department of Pharmaceutics and Center for New Drugs Research,College of Pharmacy,Third Military Medical University,Chongqing 400038,China);Alteration of vascular remolding and blood pressure in rat offsprings following maternal exposure to LPS during pregnancy[J];Acta Academiae Medicinae Militaris Tertiae;2009-07
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HONG Liang,YANG Wen-ming.(Department of Neurology,Chinese Medicine Hospital of Anhui Province,Hefei 230031,China);Alzheimer Disease and Pro-inflammatory Cytokine[J];Medical Recapitulate;2006-10
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Xiong1,LIAO Qian-de2,CAO Huan-xin2,HUANG Jian-jun2(1.Department of Orthopedics,Hunan Children's Hospital,Changsha 41007;2.Department of Orthopedics,Xiangya Hospital,Central South University,Changsha 410008);Effect of extract of horse chestnut seeds(aescuven forte)on IL-6,IL-1β and TNF in patients with limb trauma[J];Central South Pharmacy;2009-10
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 XU Tao1),ZENG Bangxiong2),LI Shizhong1) 1)Department of Anesthesiology,Beijing Jishuitan Hospital,Beijing 100035 2)Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;Influence of LPS on the expression of MMP-8 mRNA in cultured rat neutrophils[J];Journal of Zhengzhou University(Medical Sciences);2008-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved