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《Acta Academiae Medicinae Militaris Tertiae》 2008-10
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Coating for dexamethasone-eluting intravascular stent and its drug sustained release in vitro

CHEN Yong-peng1,3,WANG Gui-xue3,CHEN Yan2,JIN Xian-chun1,HOU Yan-bin3,LUO Lai-long3,SUN Da-gui4(1Department of Traditional Chinese Medicine,2Institute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037;3College of Bioengineering,4College of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400044,China)  
Objective To prepare the coating of dexamethasone-eluting intravascular stent and observe the features of its delayed release in vitro.Methods Spray painting and dipping coating were used respectively to prepare stent coating,and then high performance liquid chromatography(HPLC)was used to detect the drug loading.The stents prepared by dipping coating were set in a flow of 50 ml PBS buffer at a velocity of 20 ml/min,and 0.5 ml buffer was collected at 6 h and 1,2,4,6,8,10,12,15 d respectively with another 0.5 ml fresh PBS being added immediately.The drug content of the 0.5 ml buffer was detected by HPLC for drug sustained release in vitro.Results The drug loading of stents prepared by spray painting was(24.26±5.23)μg,while that stents prepared by dipping coating for 4 d was(93.15±7.83)μg.Drugs were released slowly and the release rate reached 84% at 15 d.Conclusion The dipping coating-prepared stents have evident effect of sustained release.
【Fund】: 国际科技合作重点项目(2004DFA06400);; 第三军医大学中青年基金(06XG030);; 重庆市科技攻关项目(2006AA5014-3);; 重庆市发改委产业化前期项目(2005-1006)~~
【CateGory Index】: R94
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1 WANG Jian-bo~* YANG Jian-yong CHEN Wei ZHUANG Wen-quan ZHANG Long-juan LI Jia-ping.~*Department of Interventional Radiology,The 6th People's Hospital,Shanghai Jiaotong University,Shanghai 200233, China YANG Jian-young,Laboratory of Surgery,The First Affiliated Hospital,SUN Yet-sen University,Guangzhou 510080,China;Experimental study on effect of dexamethasone to the in-stent restenosis after vascular intervention[J];Journal of Interventional Radiology;2007-03
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1 ZHANG Ying1,LIU Xiao-qiao2 1.Department of Cardiology,the Second People's Hospital of Jiaozuo City,Jiaozuo 454100,China;2.Department of Cardiology,Guizhou Province People's Hospital,Cardiovascular Disease Institute,Guiyang 550002,China;Change study of hsCRP with dexamethasone intervention after different numbers of coronary stent implantation[J];Clinical Focus;2010-05
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1 Shi Xiaoqun, Xiao Jiumei, Ma Wenjiang, Gong Chunxiu (Department of Applied Science, Beijing University of Science and Technology, Beijing 100083 , China);APPLICATION OF SILANE COUPLING AGENTS IN THE IMPROVING COMPATIBILITY AND MODIFICATION OF POLYMER COMPOSITES[J];Engineering Plastics Application;2002-07
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