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《Acta Academiae Medicinae Militaris Tertiae》 2008-10
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Coating for dexamethasone-eluting intravascular stent and its drug sustained release in vitro

CHEN Yong-peng1,3,WANG Gui-xue3,CHEN Yan2,JIN Xian-chun1,HOU Yan-bin3,LUO Lai-long3,SUN Da-gui4(1Department of Traditional Chinese Medicine,2Institute of Respiratory Diseases,Xinqiao Hospital,Third Military Medical University,Chongqing 400037;3College of Bioengineering,4College of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400044,China)  
Objective To prepare the coating of dexamethasone-eluting intravascular stent and observe the features of its delayed release in vitro.Methods Spray painting and dipping coating were used respectively to prepare stent coating,and then high performance liquid chromatography(HPLC)was used to detect the drug loading.The stents prepared by dipping coating were set in a flow of 50 ml PBS buffer at a velocity of 20 ml/min,and 0.5 ml buffer was collected at 6 h and 1,2,4,6,8,10,12,15 d respectively with another 0.5 ml fresh PBS being added immediately.The drug content of the 0.5 ml buffer was detected by HPLC for drug sustained release in vitro.Results The drug loading of stents prepared by spray painting was(24.26±5.23)μg,while that stents prepared by dipping coating for 4 d was(93.15±7.83)μg.Drugs were released slowly and the release rate reached 84% at 15 d.Conclusion The dipping coating-prepared stents have evident effect of sustained release.
【Fund】: 国际科技合作重点项目(2004DFA06400);; 第三军医大学中青年基金(06XG030);; 重庆市科技攻关项目(2006AA5014-3);; 重庆市发改委产业化前期项目(2005-1006)~~
【CateGory Index】: R94
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