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《Journal of Third Military Medical University》 2012-01
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Adjuvant chemotherapy for postoperative resectable colon cancer:consensus and controversy

Liang Houjie,Li Jianjun(Department of Oncology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China)  
Standard surgical treatment for localized colon cancer is radical resection of primary and regional lymph nodes.Stage Ⅰ patients do not need any adjuvant therapy after resection.While,adjuvant chemotherapy has proven benefit in stage Ⅲ colon cancer.At present,its potential value for stage Ⅱ colon cancer remains controversial.Currently,6 months of adjuvant chemotherapy following primary surgical treatment has been recommended as standard care for stage Ⅲ patients.Some evidence does not support a widespread use of adjuvant therapy in stage Ⅱ colon cancer.However,in our views of points,some high-risk stage Ⅱ patients,defined as those with poor prognostic features including T4 tumors,poor histological grade(grade 3 or 4 lesions),lymphovascular invasion,perineural invasion,bowel obstruction,lesions with localized perforation or close,indeterminate,or positive margins,and inadequately sampled nodes(less than 12 lymph nodes),should be considered for adjuvant chemotherapy.Irinotecan and target agents such as bevacizumab,cetuximab,or panitumumab must be avoided in the adjuvant setting.Perioperative regional liver chemotherapy has not been proven to reduce the rate of liver metastases or improve overall survival for resected colon cancer patients.
【CateGory Index】: R735.35
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【Co-citations】
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