Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Third Military Medical University》 2012-01
Add to Favorite Get Latest Update

Adjuvant chemotherapy for postoperative resectable colon cancer:consensus and controversy

Liang Houjie,Li Jianjun(Department of Oncology,Southwest Hospital,Third Military Medical University,Chongqing,400038,China)  
Standard surgical treatment for localized colon cancer is radical resection of primary and regional lymph nodes.Stage Ⅰ patients do not need any adjuvant therapy after resection.While,adjuvant chemotherapy has proven benefit in stage Ⅲ colon cancer.At present,its potential value for stage Ⅱ colon cancer remains controversial.Currently,6 months of adjuvant chemotherapy following primary surgical treatment has been recommended as standard care for stage Ⅲ patients.Some evidence does not support a widespread use of adjuvant therapy in stage Ⅱ colon cancer.However,in our views of points,some high-risk stage Ⅱ patients,defined as those with poor prognostic features including T4 tumors,poor histological grade(grade 3 or 4 lesions),lymphovascular invasion,perineural invasion,bowel obstruction,lesions with localized perforation or close,indeterminate,or positive margins,and inadequately sampled nodes(less than 12 lymph nodes),should be considered for adjuvant chemotherapy.Irinotecan and target agents such as bevacizumab,cetuximab,or panitumumab must be avoided in the adjuvant setting.Perioperative regional liver chemotherapy has not been proven to reduce the rate of liver metastases or improve overall survival for resected colon cancer patients.
【CateGory Index】: R735.35
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 ZHAO Rong1),HU Li-Ling1),KONG Fan-Qiang2),ZUO Ai-Jun3)*(1)Tianjin People's Hospital,Tianjin 300191,China;2)General Hospital of Tianjin Medical University,Tianjin 300052,China; 3)University of Southern California,CA 91016,USA);Association Between Pregnane X Receptor Gene Exon3 Methylation with 5-Fluorouracil Resistance of the Colon Cancer Cells[J];Chinese Journal of Biochemistry and Molecular Biology;2013-01
Chinese Journal Full-text Database 1 Hits
1 XU Chun-lei,TANG Yong(Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi,830011,China);Analysis of prognostic factors in patients with stage Ⅱ colon cancer[J];Journal of Practical Oncology;2012-03
Chinese Journal Full-text Database 10 Hits
1 WANG Guo-Qiang1,2, WAN De-Sen1,2, ZHOU Zhi-Wei1,2, PAN Zhi-Zhong1,2, CHEN Gong1,2, LU Zhen-Hai1,2, FANG Yu-Jing1,2, WU Xiao-Jun1,2, LI Li-Ren1,2, DING Pei-Rong1,2 1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China 2. Department of Abdominal Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Efficacy and Toxicity of FOLFOX6 Regimen in Treating Colorectal Cancer Patients with Liver Metastasis[J];Chinese Journal of Cancer;2007-04
2 Wang Yongshun Wang Yantao Department of Oncology,Qingdao Eighth Hospital,Qingdao 266100,China;Theatment of advanced colorectal carcinoma by Shenyi capsule and XELOX regimen in elders[J];Oncology Progress;2011-04
3 ZHAO Hai-yan1,TU De-jing2,XIA Xi2,GUO Yong3(1Jianggan Area Hospital of TCM,HangZhou 310016,China;2Cangnan Hospital of TCM,Cangnan 325800,China;3Zhejiang Hospital of TCM,Hangzhou 310006,China);Study on TCM syndrome of colorectal carcinoma in adjuvant therapy period on 151 cases[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-04
4 MU LI-xin,JIANG Jun-zuo,FAN Jie-hua(Affiliated Xinhua Hospital,Dalian University,Dalian 116021,China);Observation on treatment effect of 30 cases acupuncture therapy after large intestine cancer operation[J];Journal of Dalian University;2006-06
5 ;晚期大肠癌应用FOLFOX4方案治疗的临床疗效观察[J];Contemporary Medicine;2011-36
6 ;FOLFOX方案在中晚期大肠癌治疗中的安全性观察[J];Contemporary Medicine;2012-03
7 Wang Fengting,Zheng Hongxia(Department of Oncology,the First People's Hospital of Qujing,Qujing 655000,China);Analysis of Short-Term Effects of FOLFOX4 as First-Line Treatment on Advanced Colorectal Carcinoma[J];Journal of Basic and Clinical Oncology;2009-02
8 HONG Yang(Guangdong Province,Chaoyang District People's Hospital of Shantou,Shantou 515100);The clinical effect observation on FOLFOX4 program used in colon cancer in later period[J];Jilin Medical Journal;2010-21
9 JIANG Qin,ZHU Hong(Dept.of Pharmacy,The 1st People'sHospital of Zhao Tong,Thaotong Yunnan 657000,China);Clinical Study of Kangai Injection Combined with FORFIRI Chemotherapy in the Treatment of 30 Cases of Advanced Colon Cancer[J];Journal of Kunming Medical University;2011-09
10 HE Li-li,SUN Gui-zhi(Department of Oncology,Guang’an men Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China);Professor SUN Gui-zhi's Experience of Treating Colon Cancer[J];Journal of Liaoning University of Traditional Chinese Medicine;2009-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved