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《Journal of Third Military Medical University》 2012-01
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Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer

Long Chi,Hu Yide,Cao Zhenghuai(Cancer Research Center,Xinqiao Hospital,Third Military Medical University,Chongqing,400037,China)  
Objective To study the value of protein chip system-detected multi-tumor markers for the diagnosis of colorectal cancer(CRC).Methods Serum tumor markers were detected with C-12 in 130 CRC patients(CRC group) and 108 normal adults(control group).TNM staging of CRC,C-12 containing 12 tumor markers and their positive rate between the two groups were analyzed.Results The positive rate of C-12 was significantly higher in CRC group than in control group and increased with the TNM staging(P0.01).The positive rates of CEA,CA242 and CA19-9 were significantly higher than those of the other 9 tumor markers(P0.01).Combined CEA and CA242 or CA19-9 increased the diagnosis rate of CRC.However,no significant difference was found in the diagnosis rate of CRC between combined CEA and 12 tumor markers or single CEA(P0.05).Conclusion C-12 contributes to the diagnosis of CRC.The later the TNM staging of CRC is,the higher the value of tumor markers is.The diagnosis value of CEA,CA242 and CA19-9 for the diagnosis of CRC is better than that of the other 9 tumor markers.Detection of multiple tumor markers is not advantageous to the detection of single CEA for the diagnosis of CRC.
【CateGory Index】: R735.3
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