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《Journal of Third Military Medical University》 2012-01
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Value of protein chip system-detected multi-tumor markers for diagnosis of colorectal cancer

Long Chi,Hu Yide,Cao Zhenghuai(Cancer Research Center,Xinqiao Hospital,Third Military Medical University,Chongqing,400037,China)  
Objective To study the value of protein chip system-detected multi-tumor markers for the diagnosis of colorectal cancer(CRC).Methods Serum tumor markers were detected with C-12 in 130 CRC patients(CRC group) and 108 normal adults(control group).TNM staging of CRC,C-12 containing 12 tumor markers and their positive rate between the two groups were analyzed.Results The positive rate of C-12 was significantly higher in CRC group than in control group and increased with the TNM staging(P0.01).The positive rates of CEA,CA242 and CA19-9 were significantly higher than those of the other 9 tumor markers(P0.01).Combined CEA and CA242 or CA19-9 increased the diagnosis rate of CRC.However,no significant difference was found in the diagnosis rate of CRC between combined CEA and 12 tumor markers or single CEA(P0.05).Conclusion C-12 contributes to the diagnosis of CRC.The later the TNM staging of CRC is,the higher the value of tumor markers is.The diagnosis value of CEA,CA242 and CA19-9 for the diagnosis of CRC is better than that of the other 9 tumor markers.Detection of multiple tumor markers is not advantageous to the detection of single CEA for the diagnosis of CRC.
【CateGory Index】: R735.3
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Chinese Journal Full-text Database 7 Hits
1 ZHONG Zhao-yang,WANG Dong,LI Zeng-peng,et al.(1.Cancer Center,Daping Hospital and Surgery Research Institute,Third Military Medical University,Chongqing 400042,China;2.Department of Pathology,Daping Hospital and Surgery Research Institute,Third Military Medical University,Chongqing 400042,China);Clinical significance of C-12 multiple tumor marker protein chip detective system in diagnosing colorectal carcinoma[J];Chongqing Medicine;2007-23
2 ZHONG Zhao-yang1, WANG Dong1, LI Zeng-peng2, LI Meng-xia1, DAI Nan1, CAO Xiao-jing1, WANG Jia1, GUAN Wei1 (1Cancer Center, 2Department of Pathology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China);C-12 multiple tumor marker protein chip detection system in diagnosis of tumor[J];Acta Academiae Medicinae Militaris Tertiae;2008-17
3 CHEN Chuang1,CHEN Liqin2,YANG Guoliang1,LI Yan11Dept.of Oncology,Zhongnan Hospital of Wuhan University & Cancer Center of Wuhan University,Wuhan 430071,China2Xianning Center Hospital of Hubei Province,Xianning 437100,China;Value of Tumor Markers in Diagnosis and Monitoring of Colorectal Cancer and Strategies for Further Improvement[J];Medical Journal of Wuhan University;2007-02
4 WANG Bingji,FAN Biao,XIONG Bin Dept.of Oncology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Clinic Value of the Protein Chip System for Multi-Tumor Markers in the Diagnosis of Colorectal Cancer[J];Medical Journal of Wuhan University;2010-01
5 HUANG Chen, TANG Hanhong, WANG Minmin Department of Clinical Laboratory, Central Hospital of Wuhan, Wuhan 430014, China;Evaluation of Multi Tumor Markers using Protein Chip and Electrochemiluminescence Immunoassay[J];Tianjin Medical Journal;2008-12
6 ZHOU Wei,HUANG Lin-ping,WEI Jia-ming,et al.;Dynamic Surveillance CEA,CA199 and CA242 for Predicting Treatment Outcome and Prognosis in 82 Cases with Colorectal Carcinoma[J];Journal of Oncology;2009-06
7 YANG Xueqin,CHEN Chuang,HOU Jinxuan,et al.Medical School,Jingchu College of Technology,Jingmen 448000,CHINA;Value of C12 tumor markers protein chip in diagnosis of colorectal cancer[J];Jiangsu Medical Journal;2009-01
Chinese Journal Full-text Database 10 Hits
1 PU Ping,LI Guang-hui,LI De-zhi,et al.(Military Cancer Research Institute,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Clinical significance of determination of serum levels of four tumor carbohydrate antigens in patients with non small cell lung cancer[J];Chongqing Medicine;2009-05
2 YANG Xue-qin1,ZHONG Zhao-yang1,WANG Dong1,et al.(1.Cancer Center;2.Department of Pathology,Daping Hospital and Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China);Clinical significance of C-12 multiple tumor marker protein chip in monitoring of gastrointestinal cancer and the establishing of the discriminated function for the recurrence and metastasis[J];Chongqing Medicine;2010-04
3 Yu Ling1,Yu Jinjin1,Huang Yuzheng2,Xu Ming2,Pu Hong1(1.Department of Obstetrics and Gynecology,the Fourth Affiliated Hospital of Suzhou University,Wuxi 214062,China;2.Jiangsu Institute of Parasitic Diseases,Wuxi 214064,China);Mass spectrometry analysis of serum proteins from patients with recurrent ovarian cancer[J];Chongqing Medicine;2011-01
4 Li Shenke1,2,Chai Yurong2,Zhang Chunxia3,Lu Zhaoming3,Wang Kaijuan3,Dai Liping3,Zhang Jianying3 (1Department of Oncology,General Hospital of Puyang Oil Field,Puyang,Henan Province,457001;2Department of Histology and Embryology,College of Basic Medicine,Zhengzhou University,Henan Province,Zhengzhou,450001;3Henan Provincial Key Laboratory of Tumor Epidemiology,Zhengzhou University,Zhengzhou,Henan Province,450001,China);Application of tumor-associated antigen p62 in immunodiagnosis of carcinoma: A Meta-analysis[J];Journal of Third Military Medical University;2011-03
5 ZHONG Zhao-yang1,QING Yi,LI Meng-xia,et al.1Cancer Center,Institute of Field Surgery,The Affiliated Daping Hospital of the Third Military Medical University,Chongqing 400042,China;Diagnostic Function Based on Multiple Tumor Markers in Ovarian Cancer by Bayesian Methods:Establishment and Clinical Significance[J];Military Medical Journal of South China;2009-01
6 ZHONG Zhao-yang,WANG Dong,LI Meng-xia,PENG Bin,LI Zeng-peng,CAO Xiao-jing.Cancer Center,Research Institute of Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China;Establishment of multiple tumor marker discriminant function,its clinical significance for tumor diagnosis,and the differences with C-12 protein chip based on Bayes method[J];Medical Journal of Chinese People's Liberation Army;2009-01
7 GU Hua-pinga,SHANG Pei-zhongb(The 251st Hospital of PLA a.Department of Pathology;b.Department of General Surgery,the 251st Hospital of PLA,Zhangjiakou,Hebei 075000,China);Relationship between Expressions of CDX2 and CA242 Protein in Colorectal Cancer and its Clinicopathological Features in Elderly Patients[J];Medical & Pharmaceutical Journal of Chinese People's Liberation Army;2012-01
8 Li Yangmin,Hu Huiquan,Zhou Mi,Department of Obstetrics and Gynecology,the Central Hospital of Nanchong City,Sichuan Province,637000,P.R.China;Multiple Linear Regression Model of B-ultrasound,CT and MRI in Early Noninvasive Diagnosis of Ovarian Cancer and Its Significance[J];Journal of Military Surgeon in Southwest China;2012-01
9 HUANG Wu-jiao*,ZHEN Zhi-ming,LIN Su-xiang,XU Ning,HUANG Xian-zhang,ZHUANG Jun-hua.*Department of Laboratory,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China;Application of combined determination of CEA and CA724 in the diagnosis of colorectal cancer[J];The Journal of Practical Medicine;2011-12
10 CHEN Qubo,HUANG Wujiao,LI Cuicui,JIANG Li,DING Haiming,XIAO Qian,HUANG Sudan.(Department of Clinical Laboratory,Guangdong Provincial Hospital of Chinese Medicine,Guangdong Guangzhou 510120,China);Comparison research of Array-ELISA and ECLIA in determination of six tumor markers in serum[J];Laboratory Medicine;2012-01
China Proceedings of conference Full-text Database 1 Hits
1 CHEN Chuang~1 CHEN Liang-Dong~1 ZHANG Zhi-Ling~2 LI Yan~1 1.Department of Oncology/Cancer Prevention & Treatment Research Center,Zhongnan Hospital,Wuhan University,Wuhan,Hubei,P.R.China 2.College of Chemistry & Molecular Sciences,Wuhan University,Wuhan,Hubei,P.R.China;Advances in the Application of Quantum Dots in Tumor Markers Investigation[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Liang-Dong1, LI Yan1, YUAN Hong-Yin1, PANG Dai-Wen2 1. Department of Oncology/Cancer Prevention & Treatment Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, P. R. China 2. College of Chemistry & Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China;Quantum Dots and Their Applications in Cancer Research[J];Chinese Journal of Cancer;2006-05
2 Peng Li,Zhu Chuanjin,Liu Yuhong,et al.Department of Laboratory,Shandong Tumor Hospital(250117);Study on the Clinical Application of Combined Measurement of Serum Levels of CEA,CA199 and CA242 for the Diagnosis and Follow-Up of Patients with Cancer of Large Intestine[J];Journal of Radioimmunology;2006-03
3 ZHENG Shu Cancer Institute,Zhejiang University,Hangzhou310009,P,R,China;Prevention of colorectal carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2006-01
4 LIANG Zhu, WANG Hai-feng, WU Ai-zhu, et al. (Department of Central Laboratory of Hainan Provincial People's Hospital, Haikou 570311, Hainan, P. R. China);Clinical value of 12 tumor markers protein biochip in detection of digestive system neoplasm.[J];China Tropical Medicine;2005-03
5 YU Da-yang. (Laboratory of Check-up Center of Astraunot Navigation General Hospital, Beijing 100076, P. R. China);Application of multi-tumor markers protein chip assistance diagnostic system for detection of various tumor.[J];China Tropical Medicine;2005-03
6 JIANG Zhi-jun,ZHOU Wei-xin,LIN Wei,HUANG Qian-xiong (Department of Clinical Laboratory,Yongzhou People's Hospital,Hunan Yongzhou 425008,China);Application of Multi-tumor Markers Protein Chip Diagnose System in the Diagnosing of Intestinal Neoplasms[J];Journal of Medern Laboratory Medicine;2005-01
7 ZHANG Xin-li,ZHOU Jian-ping,WANG Chun-mei,et al.The People's Hospital of Shanxi,Xi'an 710068,China.;Clinical application of protein biochip system for detecting multi-marker of tumor.[J];Journal of Modern Oncology;2005-06
8 WANG Wei, WANG An-lan, WEN Xiao-ping(Hunan Tumor Hospital, Changsha 410006, China);Multiple Tumor Markers Protein Biochip in Detection of Lung Cancer and its Application Value[J];Journal of Oncology;2005-01
9 Mou Jianghong, Li Zengpeng, Wang Dong, Ma Yu, Xiao Hualiang, Zhang Qinhong. Department of (Pathology,) Daping Hospital, Third Military Medical University, Chongqing 400042, China;Combined detection of multiple tumor marker and its diagnostic value in colorectal cancer[J];Digestive Surgery;2005-04
10 SHEN Hui qin, GUO Wen dong, SHI Shui sheng et al The 2nd Hospital,Shanxi Medical University,Taiyuan,030001;Diagnostic value of CA19-9 and CA242 in digestive tract tumors[J];Chinese Journal of Clinkal Oncology and Rehabilitation;2001-02
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