Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Third Military Medical University》 2012-01
Add to Favorite Get Latest Update

Efficacy and safety of autologous bone marrow stem cells transplantation for type 2 diabetes mellitus

Yao Jinping,Duan Lian,Tong Qiang,Xu Zihui(Department of Endocrinology,Xinqiao Hospital,Third Military Medical University,Chongqing,400037,China)  
Objective To study the efficacy and safety of autologous bone marrow stem cells(BMSCs)transplantation via dorsal pancreatic artery(DPA)for type 2 diabetes mellitus(T2DM).Methods Six T2DM patients aged 45.67±14.92 years(3 males and 3 females) admitted to our department from June 2009 to April 2011 were enrolled in this study.The patients underwent BMSCs transplantation.Their bone marrow was mobilized and collected.BMSCs were isolated and infused into the DPA.Changes in fasting and postprandial blood glucose level,glycosylated hemoglobin(HbA1c) value,function of pancreatic islets,area under curve for C-peptide(AUCC),and insulin dose were observed.Adverse reactions of BM-SC transplantation for T2DM were recorded during and after operation with its safety and efficacy assessed.Results The HbA1c value decreased from(10.33±2.78)% before operation to(7.05±0.90)% after operation,which was 7% in 2 patients.The fasting C-peptide(FC-P)level increased from(0.71±0.54) ng/ml before operation to(1.54±0.63) ng/ml after operation.The 2 h postprandial C-peptide(2 h C-P)level increased from(1.63±0.88) ng/ml before operation to(4.67±2.31) ng/ml after operation.The mean AUCC increased from(2.29±1.31) ng/ml before operation to(6.05±2.94) ng/ml after operation.The insulin dose decreased from(27.17±13.08) U/d before operation to(18.63±7.04) U/d after operation.Subcutaneous insulin injection was withdrawn in 2 patients who changed to have oral hypoglycemic drugs.No adverse reaction occurred during autologous BMSCs transplantation and follow-up.The tumor markers and amylase level were normal before and after BMSCs transplantation.Conclusion Autologous BMSCs transplantation can improve the function of pancreatic islets of T2DM patients and decrease their dependence on hypoglycemic drugs with rather good safety.
【CateGory Index】: R587.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Wang Pan1,Wu Zheng-rong1,Tian Jing-lun2,Qi Long11ICU Department,2Department of Endocrinology,Wenjiang People's Hospital,Chengdu 611130,Sichuan Province,China;Autologous bone marrow cell transplantation via spleen artery in 5 patients with type 2 diabetes mellitus[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-23
2 LI Li-rong,SHEN Shan-mei,SHANGGUAN Hai-yan,et al.The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Therapeutic effects and safety of autologous hematopoietic stem cell transplantation in Newly-diagnosed type 1 diabetic patients[J];Chinese Journal of Diabetes;2010-10
3 Xiao-Hong Wu, Cui-Ping Liu, Kuan-Feng Xu, Xiao-Dong Mao, Jian Zhu, Jing-Jing Jiang, Dai Cui, Mei Zhang, Yu Xu, Chao Liu Xiao-Hong Wu, Cui-Ping Liu, Kuan-Feng Xu, Xiao-Dong Mao, Jian Zhu, Jing-Jing Jiang, Dai Cui, Mei Zhang, Yu Xu, Chao Liu, Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China;Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells[J];世界胃肠病学杂志(英文版);2007-24
Chinese Journal Full-text Database 5 Hits
1 XU Gugen YANG Yin YIN Zhuona LI Ping XIAO Yi ZHAO Hongli WENG Yu FU Xiaoying Department of Endocrinology,the Second People's Hospital in Guangdong Province,Guangzhou 510010,China;The clinical observation of umbilical cord blood stem cell transplantation on the treatment of type 2 diabetes[J];China Medicine and Pharmacy;2011-22
2 XIE Hong-bin,QI Hui,LI Fu-rong(Clinical Research Center,the Second Clinical Medical College Shenzhen People's Hospital,Jinan University,Shenzhen 518020,China);The mechanism of mesenchymal stem cell therapy for diabetes[J];Basic & Clinical Medicine;2010-08
3 WANG Ying-li,LIU Chang,MEI Xi-fan,GUO Zhan-peng,LI Quan-shuang. Department of Endocrinology,First Affiliated Hospital of Liaoning Medical University,Jinzhou,Liaoning 121001,China;Differentiation of muscle-derived stem cells into insulin-producing cells in neonatal rats[J];Medical Journal of Chinese People's Liberation Army;2010-04
4 Chen Guo-chang 1,Wang Xi-ran 2 1 Affiliated Beijing Obstetrics and Gynecology Hospital of Capital Medical University,Beijing 100006,China;2 Second Artillery General Hospital,Beijing 100088,China;Stem cells transplantation in the treatment of diabetes[J];Chinese Journal of Tissue Engineering Research;2012-36
5 Yuan Liu, Chun-Shui He, Yang Liu, Li-Feng Zhang, Wei Zeng, Vascular Surgery and Interventional Radiology Center, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China Qiu Chen, Endocrine Department, Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China;Superselective peripancreatic arterial catheterization for infusion of autologous bone stem cells in diabetic patients: An analysis of 24 cases[J];World Chinese Journal of Digestology;2013-03
Chinese Journal Full-text Database 5 Hits
1 SHI Chun meng, MAI Yue, CHENG Tian min, SU Yong ping, XU Hui, ZHENG Huai en, WANG Jun ping, HUANG Yue sheng, JIANG Jian xin (State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China);Spontaneous malignant transformation of dermis-derived adult multipotential stem cells in vitro[J];Acta Academiae Medicinae Militaris Tertiae;2004-01
2 Zhang Cai-long1, Xia Chang-suo1, Jiang Zheng-yao21Department of Orthopaedics, Hospital Affiliated to Medical College, Qingdao University, Qingdao 266003, Shandong Province, China; 2Department of Physiology, Medical College, Qingdao University, Qingdao 266021, Shandong Province, China;Isolation of rabbit bone marrow mesenchymal stem cells using density gradient centrifugation and adherence screening methods[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-06
3 Hu Wei1,Yu Xing2,Zhu Ling-qun3,Xu Lin2,Wang Shuo-ren31Second Department of Spinal Surgery,Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region,Urumchi 830000,Xinjiang Uygur Autonomous Region,China;2Department of Orthopedics,3Central Laboratory,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Biological characteristics of human bone marrow-derived mesenchymal stem cells at different passages:Third to sixth passages are recommended for clinical application[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2009-49
4 CHAI Gang, ZHANG Yan, HU Xiao_jie, WANG Min, LIU Wei, CUI Lei, CAO Yi-lin. Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Second Medical University, Shanghai Tissue Engineering Center, Shanghai 200011, China;Repair alveolar cleft bone defects with bone marrow stromal cells[J];Chinese Journal of Plastic Surgery;2006-06
5 ;体外长期培养对人骨髓间充质干细胞生物学特性的影响[J];Journal of Tissue Engineering and Reconstructive Surgery;2005-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 SHEN Shan-mei,LI Li-rong,ZHU Da-Ling,et al.The Af filiated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Therapeutic effect of autologous hematopoietic stem cell transplantation in one newly-diagnosed type 1 diabetic patient[J];Chinese Journal of Diabetes;2008-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved