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《Journal of Third Military Medical University》 2012-19
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Methylation of RUNX3 gene promoter in HCC and its significance

Li Jianguo 1,Jiang Xiaojie 2(1 Department of Hepatobiliary Surgery,Affiliated Zhangzhou Hospital of Fujian Medical University,Zhangzhou,Fujian Province,363000;2 Department of Tumor Surgery,Affiliated Putian Hospital of Putian College,Putian,Fujian Province,351100,China)  
Objective To study the relation between methylation of human runt-related transcription factor 3(RUNX3) gene promoter in hepatocellular carcinoma(HCC) and clinical characteristics of HCC patients.Methods Tumor tissue and its adjacent tissue samples were taken from 95 patients of HCC and 20 normal controls,respectively.Of the 95 HCC patients,57 were complicated with cirrhosis and divided into group A(n=36),group B(n=11) and group C(n=10) according to their liver function Child-Pugh score.Methylation of RUNX3 gene promoter(CpG island) was detected by methylation-specific PCR and its relation with the clinical characteristics of HCC patients was analyzed.Results The abnormal methylation of RUNX3 gene promoter(CpG island) was detected in tumor tissue and its adjacent tissue samples from 45.3%(43/95) and 9.5%(9/95) patients,respectively(P0.01),but not detected in normal liver tissue samples.The methylation of RUNX3 gene promoter(CpG island) was closely correlated with cirrhosis and cancer embolus formation in portal vein(P0.05).The methylation level of RUNX3 gene promoter(CpG island) was significantly higher in group C than in groups A and B(P0.05).Conclusion One of the major reasons for the abnormal methylation of RUNX3 gene promoter(CpG island) in HCC patients is the down-regulated expression of CpG island due to its methylation.Abnormal methylation of RUNX3 gene promoter(CpG island) is closely correlated with cirrhosis and cancer embolus formation in portal vein.
【Fund】: 福建省自然科学基金(2009J01326)~~
【CateGory Index】: R894.3
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